有机化学 ›› 1999, Vol. 19 ›› Issue (2): 162-165. 上一篇    下一篇

研究论文

2, 6-二烷氧基(羟基)苯乙酮的苄腙和甲腙合成吲唑类化合物

邱国福;邱玉珠;张正;胡宏纹   

  1. 南京大学化学化工学院化学系
  • 发布日期:1999-04-25

The synthesis of indozoles from substituted hydranones of 2, 6- dialkoxyl(hydroxyl) acetophenones

Qiu Guofu;Qiu Yuzhu;Zhang Zheng;Hu Hongwen   

  • Published:1999-04-25

在多聚磷酸(PPA)存在下,2,6-二烷氧基(羟基)苯乙酮的苄腙和甲腙可以发生环化反应,生成产率较高的吲唑类化合物。根据实验结果,我们推测反应的关键步骤为亲核进攻。化合物的结构均经元素分析、IR、^1HNMR和MS确定。

关键词: 吲唑P, 苯乙酮P, 质子磁共振谱法, 聚磷酸, 元素分析, 质谱法, 红外分光光度法, 环化, 腙P

In the presence of PPA, 2, 6-dialkoxyl (hydroxyl) acetophenone hydrazones were cyclized to give indazoles. According to the experimental resutls, it was assumed that the cyclization was taken by nucleophilic attack. All the new compound were identified by elemental and spectral analyses.

Key words: MASS SPECTROGRAPHY, INDAZOLE P, INFRARED SPECTROPHOTOMETRY, ELEMENTAL ANALYSIS, PROTON MAGNETIC RESONANCE SPECTROMETRY, ACETOPHENONE P, CYCLIZATION, HYDRAZONE P

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