有机化学 ›› 2000, Vol. 20 ›› Issue (5): 738-742. 上一篇    下一篇

研究论文

含三氟甲基均三唑环的Mannich碱的合成

刘方明;王宝雷;鲁文杰   

  1. 新疆大学化学系.新疆(830046);五邑大学化工系
  • 发布日期:2000-10-25

synthesis of trifluormethyl-substituted 1,2,4-triazole mannich bases

Liu Fangming;Wang Baolei;Lu Wenjie   

  1. Xinjiang Univ, Dept Chem.Xinjiang(830046)
  • Published:2000-10-25

以3-三氟甲基-4-氨基-5-巯基-1,2,4-三唑(1)为原料,与芳醛在冰醋酸中缩合得相应Schiff碱(2~5),(2~5)与各种仲胺和芳胺在室温下反应,制得24个新的Mannich碱(6~9),利用IR,^1HNMR、MS和元素分析确定了这些化合物的结构。

关键词: 三氟甲基, 三唑P, 席夫碱, 曼尼希碱, 氮杂环化合物, 波谱分析

The reaction of 3-trifluoromethyl-4-amino-5-mercapto-1,2,4-triazole (1) with aromatic aldehydes gave the Schiff bases(2~5). The Mannich reaction, of 2~5 led to twenty four new 1,2,4-triazole Mannich bases (6~9). The structures of these Mannich bases were confirmed by elemental analysis, IR, ^1H NMR and MS spectra.

Key words: TRIFLUOMETHYL, PYRRODIAZOLE P, SCHIFF BASE, MANNICH BASE, NITROGEN HETEROCYCLICS, SPECTROMETRIC ANALYSIS

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