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有机化学
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有机化学 ›› 2001, Vol. 21 ›› Issue (11): 1090-1094. 上一篇    

研究论文

有机硅化合物的不对称合成反应

王东   

  1. 中国科学院化学研究所分子科学中心.南京(210008)
  • 发布日期:2001-11-25

Asymmetric reactinos of organosilicon compounds

Wang Dong   

  1. Nanjing Inst Geol & Palaeontol, Acad Sinica, North-China Univ of. Nanjing(210008)
  • Published:2001-11-25

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介绍了“碳中心”手性有机硅化合物的合成，以及在烯丙基硅烷与醛的Hosomi-Sakurai反应和α-烯丙基硅碳负离子与醛的反应中的应用。提出并实践了两条提高对映选择性的途径。烯基硅醇的不对称环氧化反应扩展了Sharpless反应的适用范围，为合成光活性的具简单结构的环氧化合物提供了一条简易的途径。

关键词: 有机硅化合物, 手征性, 环氧化反应, 烯丙基, 硅烷醇, 碳中心, 不对称反应

"Carbon-centered" chiral organosilicon compounds were synthesized and applied in asymmetric HosomiSakurai reactions and asymmetric reactions of α-silylallyl arbanions with aldehydes. Two aproaches for improving the stereoselectivities were suggested and examined. The asymmetric epoxidation reactions of alkenylsilanols were carried out, which enlarged the scope of Sharpless asymmetric epoxidation and provided a convenient route to simple optically active epoxide.

Key words: ORGANO SILICON COMPOUNDS, CHIRALITY, EPOXIDATION REACTION, ALLYL GROUP, SILANOL

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