有机化学 ›› 2003, Vol. 23 ›› Issue (4): 384-386. 上一篇    下一篇

研究论文

带恶唑啉衍生物侧链的1,7-二氮-12-冠-4的合成及其应用

王成云;商志才;冷桃花;俞庆森   

  1. 浙江大学化学系
  • 发布日期:2003-04-25

Synthesis of Substituted 1,7-Diaza-12-crown-4 Containing Oxazolines and Its Application

  • Published:2003-04-25

用手性α-氨基醇和原氯乙酸三乙酯作用得到的手性恶唑啉2a-2c和1,7-二氯- 12-冠-4反应,合成了带手性侧链的1,7-二氯-12-冠-4衍生物1a-1c,并将其铜配 合物运用于重氮醋酸酯对烯烃的不对称环丙烷化反应.

关键词: 恶唑啉;冠式化合物;铜络合物;环烷基化;应用;重氮化合物;乙酸酯, 烯烃

New bibracchiral lariart crown ethers la ~lc were synthesized by treatment of 1,7-doaza-12-crown-4 with chiral oxazolines 2a~2c .2a~2c were prepared from amino alcohols and triethyl orthochloroacetate. Cu (Ⅱ) complexes of la~lc were applied to the asymmetric cyclopropanation of 1,1-diphenyl ethylene with alkyl diazoacetate.

Key words: oxazolines;CROWN ETHER COMPOUNDS;COPPER COMPLEX;CYCLOALKYLATION, APPLICATION;DIAZO COMPOUNDS;ACETIC ACID ESTER;ALKENE

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