铜催化交叉偶联反应研究的新进展

摘要/Abstract

对Cu催化交叉偶联反应的最新研究进展作了综述.该反应涉及碳—碳、碳—氮、碳—氧、碳—硫、碳—硒、以及碳—卤的成键.反应的类型包括Ullmann反应、Suzuki反应、Stille反应以及Heck反应等.还详细地介绍了Cu催化交叉偶联反应中选用不同的铜盐、配体以及溶剂时所产生的效果.

关键词: Cu催化剂, 交叉偶联反应, 绿色化学

The cross-coupling reaction of unsaturated carbonsis one of the most important methods in organic synthesis. It has been widely used in the manufactures of dyes, pharmaceuticals, polymers, and many other fine chemicals. Due to their low price and toxicity, Cu salts have recently emerged as novel catalysts in cross-coupling reactions of unsaturated carbons, whosereplacement of toxic and expensive Pd or Ni catalysts will greatly improve the chemical industry in both the economic and environmental aspects. In this reviewthe newest development of the Cu catalysts in cross-coupling reactions was summarized. C—C, C—N, C—O, C—S, as well as C—X coupling reactions were reviewed. The article also provided detail information about the effects of Cu salts, ligands and solvents on the efficiency of the cross-coupling reactions.

Key words: Cu catalyst, cross-coupling reaction, green chemistry

引用此文

邓维, 刘磊, 郭庆祥. 铜催化交叉偶联反应研究的新进展[J]. 有机化学, 2004, 24(2): 150-165.

DENG, Wei, LIU, Lei, GUO, Qing-Xiang. Recent Progress in Copper-Catalyzed Cross-Coupling Reactions[J]. Chinese Journal of Organic Chemistry, 2004, 24(2): 150-165.

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