有机化学 ›› 2005, Vol. 25 ›› Issue (12): 1610-1614. 上一篇    下一篇

研究简报

微波辐射下三组分“一锅法”合成5-芳基-1,5,6,7,8,9-六氢化-2H-吡唑[5,4-b]并喹啉-6-酮

华国平,徐佳宁,屠树江*,王倩,张金鹏,朱晓彤
李团结,朱松磊,章晓镜   

  1. (1徐州建筑职业技术学院 徐州 221008)
    (2徐州师范大学化学系 江苏省药用植物生物技术重点实验室 徐州 221116)
  • 收稿日期:2005-02-05 修回日期:2005-06-29 发布日期:2005-11-30
  • 通讯作者: 屠树江

Facile Three Component One-pot Synthesis of 5-Aryl-1,5,6,7,8,9- hexahydro-2H-pyrazolo[5,4-b]quinolin-6-one De-rivatives under Microwave Irradiation

HUA Guo-Ping, XU Jia-Ning, TU Shu-Jiang*, WANG Qian, ZHANG Jin-Peng,
ZHU Xiao-Tong, LI Tuan-Jie, ZHU Song-Lei,ZHANG Xiao-Jing   

  1. (1 Xuzhou Institute of Architectural Technology, Xuzhou 221008)
    (2 Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Department of Chemistry,
    Xuzhou Normal University, Xuzhou 221116)
  • Received:2005-02-05 Revised:2005-06-29 Published:2005-11-30
  • Contact: TU Shu-Jiang

在微波辐射下以芳醛、1,3-环己二酮或达米酮和氨基吡唑为原料, 用乙二醇作能量转移剂, 三组分“一锅法”快速合成了一系列吡唑[5,4-b]并喹啉类化合物. 该方法速度快(30~90 s), 产率高(88%~98%), 环境友好. 产物结构通过红外光谱、核磁共振谱和元素分析证实, 化合物4e的单晶经X射线衍射分析, 进一步确证了产物结构.

关键词: 吡唑并喹啉, 氨基吡唑, 微波辐射

A series of 5-aryl-1,5,6,7,8,9-hexahydro-2H-pyrazolo[5,4-b]quinolin-6-one dervatives were synthesized by the three component one-pot reaction of 5-amino-3-methyl-1-phenypyrazole with aromatic aldehydes and dimedone or 1,3-cyclohexanedione under microwave irradiation using glycol as energy trans-fer agent. This method has the advantage of excellent yields (88%~98%), short reaction time (30~90 s) and being environmental friendliness. The structures of the products were identified by IR, NMR spectra, elemental analysis and X-ray crystallograghic of 4e.

Key words: aminopyrazole, microwave irradiation, pyrazolo[5,4-b]quinoline