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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (9): 1110-1112. 上一篇    下一篇

研究简报

KF/Al2O3催化下芳醛和4-羟基喹啉-2-酮的反应研究

王香善*,1,2,3，曾兆森1，史达清1,3，屠树江1,3
魏贤勇2，宗志敏2   

  1. (1徐州师范大学化学系 徐州 221116)
    (2中国矿业大学化学工程学院 徐州 221008)
    (3江苏省药用植物生物技术重点实验室 徐州 221116)
  • 收稿日期:2004-04-19 修回日期:2005-03-24 发布日期:2005-08-24
  • 通讯作者: 王香善

Study on the Reaction of Aryl Aldehyde and 1,2-Dihydro-4-hydroxyquinolin-2-one

WANG Xiang-Shan*,1,2,3,ZENG Zhao-Sen1,SHI Da-Qing1,3,TU Shu-Jiang1,3
WEI Xian-Yong2,ZONG Zhi-Min2   

  1. (1 Department of Chemistry, Xuzhou Normal University, Xuzhou 221116)
    (2 School of Chemical Engineering, China University of Mining and Technology, Xuzhou 221008)
    (3 Key Laboratory of Biotechnology on Medical Plant, Xuzhou 221116)
  • Received:2004-04-19 Revised:2005-03-24 Published:2005-08-24
  • Contact: WANG Xiang-Shan

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以芳醛和4-羟基喹啉-2-酮为原料, 在KF/Al2O3催化下以乙醇为溶剂, 在80 ℃合成了一系列新的双(4-羟基-2-氧代喹啉-3-基)-芳基甲烷衍生物, 反应条件温和, 产率较高, 并通过IR, 1H NMR和元素分析确证产物的结构.

关键词: 4-羟基喹啉-2-酮, KF/Al2O3, 合成

A series of new bis(1,2-dihydro-4-hydroxyl-2-oxoquinolin-3-yl)arylmethane derivatives were synthesized from arylaldehyde and 1,2-dihydro-4-hydroxyquinolin-2-one in ethyl alcohol at 80 ℃, catalyzed by KF/Al2O3 under mild reaction condition in good yields. The structures of the products were confirmed by IR, 1H NMR spectra and elemental analysis.

Key words: synthesis, KF/Al2O3, 4-hydroxyquinoline-2-one