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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (01): 82-86. 上一篇    下一篇

研究论文

3-氨基-二氢噻吩-2-酮类Schiff碱的合成和生物活性研究

孙晓红*,a，李淑娟a，刘源发b，陈邦b
贾婴琦b，陶燕a   

  1. (a西北大学化学研究所 西安 710069)
    (b西北大学化学系 西安 710069)
  • 收稿日期:2006-03-04 修回日期:1900-01-01 发布日期:2006-12-30
  • 通讯作者: 孙晓红

Study on the Synthesis and Biological Activity of Schiff Bases of 3-Amino-dihydrothiophene-2-one

SUN Xiao-Hong*,a,LI Shu-Juana,LIU Yuan-Fab,CHEN Bangb
JIA Ying-Qib,TAO Yana   

  1. (a Chemical Institute, Northwest University, Xi′an 710069)
    (b Department of Chemistry, Northwest University, Xi′an 710069)
  • Received:2006-03-04 Revised:1900-01-01 Published:2006-12-30
  • Contact: SUN Xiao-Hong

PDF

1012

被引次数

20 | 9

通过3-氨基-二氢噻吩-2-酮(DL-高半胱氨酸硫内酯)盐酸盐与取代苯甲醛反应, 得到3-氨基-二氢噻吩-2-酮类Schiff碱. 合成了9个化合物, 其中7个为首次报道的新Schiff碱类化合物. 化合物结构经IR, 1H NMR和元素分析证实, 并对这些化合物进行了室内毒力测试, 结果表明此类化合物具有很好的杀菌、抑菌活性.

关键词: 3-氨基-二氢噻吩-2-酮, Schiff碱, 生物活性, 合成

Nine Schiff bases of 3-amino-dihydrothiophene-2-one were synthesized by reaction of substituted benzaldehyde with DL-homocysteine thiolactone hydrochloride by means of preferable reaction conditions. Seven of them were reported for the first time. The structures of the compounds were confirmed by elemental analysis, 1H NMR and IR spectra. The biological tests showed that they were excellent biological active to several vegetable pathogen.

Key words: Schiff base, synthesis, biological activity, 3-amino-dihydrothiophene-2-one