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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (01): 77-81. 上一篇    下一篇

研究论文

含肉桂酰胺类化合物的合成及α-糖苷酶抑制活性

蔡小华*,a,b，吴英华a   

  1. (a怀化医学高等专科学校药学系 怀化 418000)
    (b贵州民族学院化学与环境科学学院 贵阳 550025)
  • 收稿日期:2006-02-27 修回日期:1900-01-01 发布日期:2006-12-30
  • 通讯作者: 蔡小华

Synthesis and α-Glucosidase Inhibitory Activity of Cinnamic Amides

CAI Xiao-Hua*,a,b,WU Ying-Huaa   

  1. (a Department of Pharmacy, Huaihua Medical College, Huaihua 418000)
    (b College of Chemistry and Environmental Science, Guizhou University for Nationalities, Guiyang 550025)
  • Received:2006-02-27 Revised:1900-01-01 Published:2006-12-30
  • Contact: CAI Xiao-Hua

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合成了4个未见报道的含肉桂酰胺类化合物9a～9b, 初步评价了它们的α-糖苷酶抑制活性. 这些化合物均具有α-糖苷酶抑制活性, 是一类结构新颖的α-糖苷酶抑制活性化合物, 其中, 化合物9b和9c的活性高于阳性对照药物阿卡波糖.

关键词: 糖尿病, 肉桂酰胺, α-糖苷酶抑制活性, 合成

Four new cinnamic amides 9a～9d were synthesized, and their preliminarily inhibitory activities for α-glucosidase were evaluated. All of these compounds displayed inhibitory activities of α-glucosidase, and are a new structural type of α-glucosidase inhibitory compounds. The inhibitory activity of 9b and 9d was higher than those of control drug acarbose.

Key words: cinnamic amide, synthesis, α-glucosidase inhibitory activity, diabetes