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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (06): 1111-1114. 上一篇    下一篇

研究简报

1,2,4-三唑双席夫碱衍生物的合成及表征

张思行，武现丽，戴志鹏，廖新成*，卢建莎   

  1. (郑州大学化学系 化学生物学实验室 郑州 450052)
  • 收稿日期:2007-07-23 修回日期:2007-12-22 发布日期:2008-06-26

Synthesis and Characterization of the Derivatives of <br>1,2,4-Triazole Bis-Schiff Base

ZHANG Si-Xing, WU Xian-Li, DAI Zhi-Peng, LIAO Xin-Cheng*, LU Jian-Sha   

  1. (<I>Key Laboratory of Chemical Biology</i>,<i> Department of Chemistry</i>, <I>Zhengzhou University</i>, <I>Zhengzhou 450052</i>)
  • Received:2007-07-23 Revised:2007-12-22 Published:2008-06-26

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701

被引次数

27 | 8

氨基均三唑硫醇<b>1a</b>～<b>1b</b>与1,2-二溴乙烷缩合制得双氨基三唑硫醚<b>2a</b>～<b>2b</b>, <b>2a</b>～<b>2b</b>与芳香醛经缩合得相应的席夫碱<b>3a<sub>1</sub></b>～<b>3a<sub>5</sub></b>与<b>3b<sub>1</sub></b>～<b>3b<sub>7</sub></b>, 收率65%～80%. 所得席夫碱类新化合物的结构均经IR, <sup>1</sup>H NMR, MS和元素分析确证.

关键词: 均三唑, 硫醚, 合成, 席夫碱

A series of bis(amino-triazole) Schiff bases <b>3a<sub>1</sub></b>～<b>3a<sub>5</sub></b> and <b>3b<sub>1</sub></b>～<b>3b<sub>7</sub></b> were synthesized in yields of 65%～80% via the condensation of 4-amino-5-mercapto-1,2,4-triazole (<b>1a</b>～<b>1b</b>) with 1,2-dibromoethane to obtain <b>2a</b>～<b>2b</b> followed by further condensation with aryl aldehydes in acetic acid. The structures of as-synthesized products were confirmed by<b> </b>FTIR, <sup>1</sup>H NMR, ESI-MS spectra and elemental analysis.