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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (08): 1326-1335. 上一篇    下一篇

综述与进展

树枝状化合物作为药物载体的研究进展

何 谷 ; 郭 丽*   

  1. (四川大学华西药学院药物化学系 靶向药物教育部重点实验室 成都 610041)
  • 收稿日期:2007-05-09 修回日期:2007-10-08 发布日期:2008-08-18
  • 通讯作者: 郭 丽

Progress in Dendrimers as Drug Carriers

HE, Gu ; GUO, Li*   

  1. (Key Laboratory of Drug Targeting of Ministry of Education, Department of Medicinal Chemistry,
    West China School of Pharmacy, Sichuan University, Chengdu 610041)
  • Received:2007-05-09 Revised:2007-10-08 Published:2008-08-18
  • Contact: GUO, Li

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被引次数

14 | 4

树枝状化合物是一类具有规整结构和单分散性的大分子化合物, 具有不同于普通高分子化合物的独特理化性质, 广泛地应用在材料、催化以及生物医学领域中. 简要综述了树枝状化合物作为药物载体及其在抗病毒、抗肿瘤以及多肽和糖模拟物等领域的研究进展.

关键词: 树枝状化合物, 肽模拟物, 药物载体, 抗肿瘤, 抗病毒

Dendrimers are monodisperse macromolecules with strict structures, which have a lot of unique physical and chemical characteristics different from normal polymers and widely applicated to the material, catalyst and biomedical areas. Dendrimers as drug carriers and their applications to the areas of antiviral, anti-tumor, peptide and saccharide analogues are discussed.

Key words: dendrimer, antiviral, anti-tumor, peptide analogue, drug carrier