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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (9): 1553-1560. 上一篇    下一篇

综述与进展

平板霉素的全合成研究综述

姚元山a,b ; 姚祝军*,a   

  1. (a中国科学院上海有机化学研究所生命有机化学国家重点实验室 上海 200032)
    (b中国科技大学化学系 合肥 230026)
  • 收稿日期:2007-11-02 修回日期:2008-02-18 发布日期:2008-09-20
  • 通讯作者: 姚祝军

Total Synthesis of Platensimycin: a Review

YAO, Yuan-Shana,b ; YAO, Zhu-Jun*,a   

  1. (a State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry,
    Chinese Academy of Sciences, Shanghai 200032)
    (b Department of Chemistry, University of Science and Technology of China, Hefei 230026)
  • Received:2007-11-02 Revised:2008-02-18 Published:2008-09-20
  • Contact: YAO, Zhu-Jun

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平板霉素由于其强有力的抗菌能力、全新的作用机理和新颖的分子结构, 自2006年被发现起就引起了合成化学家们的广泛关注. 对平板霉素的全合成及其结构类似物的合成进行了综述和介绍.

关键词: 平板霉素, 全合成, 抗生素, 四环笼状分子骨架, 天然产物

Platensimycin represents a unique structural class of antibiotics acting with a novel and highly selective mechanism. Its potent antibacterial activity and interesting chemical structure have attracked great attention of scientific community, and have made it an attractive target for chemical synthesis. This review summarizes the total syntheses of platensimycin and its analogues since its discovery in 2006.

Key words: platensimycin, natural product, total synthesis, cage-like tetracyclic core, antibiotic