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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (9): 1522-1526. 上一篇    下一篇

研究简报

水介质中Yb(OTf)3催化下喹唑啉酮衍生物的绿色合成

王树良，盛洁，屠树江，王香善*   

  1. (徐州师范大学化学化工学院 徐州 221116)
  • 收稿日期:2011-03-16 修回日期:2011-05-18 发布日期:2011-06-29
  • 通讯作者: 王香善 E-mail:xswang1974@yahoo.com;xswang@xznu.edu.cn

Clean Synthesis of Quinazolinone Derivatives in Water Catalyzed by Yb(OTf)3

WANG Shu-Liang, SHENG Jie, TU Shu-Jiang, WANG Xiang-Shan   

  1. (School of Chemistry and Chemical Engineering, Xuzhou Normal University Xuzhou 221116)
  • Received:2011-03-16 Revised:2011-05-18 Published:2011-06-29
  • Contact: Wang Xiang-Shan E-mail:xswang1974@yahoo.com;xswang@xznu.edu.cn

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被引次数

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在水介质中, 醛或酮首先和邻氨基苯甲酰肼反应形成腙|在1 mol% Yb(OTf)3催化下, 再与另外一分子醛或酮反应, 构建一系列不同取代的喹唑啉酮衍生物. 该方法具有中性反应条件、产率高(80%～94%)、操作简单和环境友好等优点. 产物的结构通过IR, 1H NMR和HRMS表征.

关键词: 邻氨基苯甲酰肼, 喹唑啉酮, 水, Yb(OTf)3

Using water as a green reaction media, aldehydes or ketones react with 2-aminobenzohydrazide to give hydrazone firstly, and then a series of quinazolinone derivatives are obtained by the reaction of the hydrazone with another molecule of aldehyde or ketone catalyzed by 1 mol% Yb(OTf)3. This method provides several advantages such as neutral conditions, high yields (80%～94 %), simple work-up and environmental benignity. The structures were established by spectroscopic data of IR, 1H NMR and HRMS techniques.

Key words: 2-aminobenzohydrazide, quinazolinone, water, Yb(OTf)3