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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (07): 1278-1281. 上一篇    下一篇

研究简报

微波促进下苯并咪唑与芳基卤化物的偶联反应

刘影英 ; 陶 兰* ; 冯国仁   

  1. (杭州师范大学材料与化学化工学院 杭州 310036)
  • 收稿日期:2007-12-06 修回日期:2008-01-25 发布日期:2008-07-28
  • 通讯作者: 陶 兰

Microwave-Enhanced Ullmann-Coupling Reaction of Benzimidazole with (Un)substituted Phenyl Halide

LIU, Ying-Ying; TAO, Lan*; FENG, Guo-Ren   

  1. (College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036)
  • Received:2007-12-06 Revised:2008-01-25 Published:2008-07-28
  • Contact: TAO, Lan

PDF

814

被引次数

15

通过微波辐射, 苯并咪唑与多种卤素取代的芳基化合物在催化剂碘化亚铜、配体L-脯氨酸或N,N-二甲基甘氨酸的存在下, 以二甲基亚砜作溶剂, 在较低温度(75～110 ℃)下一步合成, 得到6种高产率的1-芳基取代苯并咪唑衍生物, 为该类化合物的合成提供了一种新方法. 产物通过熔点测定, 核磁共振氢谱、核磁共振碳谱、质谱等的表征.

关键词: 苯并咪唑, 芳基卤化物, 偶联反应, 微波

The copper-catalyzed Ullmann-coupling reaction of benzimidazole with (un)substituted phenyl halide gave benzimidazole derivatives in good to excellent yields in DMSO at 75～110 ℃ under microwave irradiation conditions by using either L-proline or N,N-dimethylglycine as a ligand. This method provides a simple and inexpensive access to the title compounds. The structures of the products were confirmed by melting points, 1H NMR, 13C NMR and EI-MS spectra.

Key words: benzimidazole, (un)substituted phenyl halide, Ullmann-coupling reaction, microwave