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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (12): 2081-2094. 上一篇    下一篇

综述与进展

离子液体在有机合成中的应用研究进展

应安国a,b ; 叶伟东b ; 刘 泺a,b ; 吴国锋a,b;
陈新志*,a ; 钱 胜b ; 张秋萍b
  

  1. (a浙江大学材料与化工学院 杭州 310027)
    (b浙江医药股份有限公司新昌制药厂 新昌 312500)
  • 收稿日期:2008-03-07 修回日期:2008-04-21 发布日期:2008-12-28
  • 通讯作者: 陈新志

Progress in the Application of Ionic Liquids to Organic Synthesis

YING, An-Guo a,b ; YE, Wei-Dong b; LIU, Luo a,b ; WU, Guo-Feng a,b;
CHEN, Xin-Zhi*,a ; QIAN, Sheng b; ZHANG, Qiu-Pingb
  

  1. (a College of Materials Science and Chemical Engineering, Zhejiang University, Hangzhou 310027)
    (b Xinchang Pharmaceuticals Factory, Zhejiang Medicine Co. LTD., Xinchang 312500)
  • Received:2008-03-07 Revised:2008-04-21 Published:2008-12-28
  • Contact: CHEN, Xin-Zhi

PDF

4059

被引次数

40 | 12

离子液体由于具有特殊的性质, 包括低挥发性、大极性、良好的热稳定性、通过调整阴阳离子选择不同的溶解性等特点, 已经作为反应介质或催化剂广泛应用于有机合成领域, 引起了人们足够的兴趣. 与传统有机溶剂反应相比, 离子液体相反应得到的产物收率高, 选择性好, 加快部分类型反应的速率, 后处理简单以及离子液体催化剂体系简单, 回收后, 可多次重复使用. 综述了离子液体作为反应介质或催化剂在有机合成传统反应类型中的最新研究成果, 主要包括: 偶联反应、Michael加成、Baylis-Hillman反应、Diels-Alder反应、Aldol缩合、Knoevenagel缩合、环化反应、烷基化及酰基化反应和氧化还原反应.

关键词: 有机合成, 应用, 循环使用, 离子液体

Ionic liquids, with their unique properties, including low volatility, high polarity, good thermal stability over a wide temperature range and selective dissolving capacity by a proper choice of cations or anions, have attracted increasing interest in the organic transformations as reactioin medium as well as catalyst (ligand). Compared with traditional organic solvents, ionic liquids have great advantages in obtaining products with high isolated yields and good to excellent selectivities, accelerationg reaction rate in some cases, ease of work-up, as well as recycling use with or without catalysts after simply recoveration. The paper reviews the advanced progress in the application of ionic liquids as reaction medium as well as catalysts to organic synthesis, mainly including coupling reaction, Michael addition, Baylis-Hillman reaction, Diels-Alder reaction, Aldol reaction, Knoevenagel condensation, cyclorization reaction, alkylation and acylation, oxidation and reduction etc.

Key words: cyclorization reaction, alkylation and acylation, oxidation and recycling use, Knoevenagel condensation