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有机化学
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有机化学 ›› 1999, Vol. 19 ›› Issue (5): 519-522. 上一篇    下一篇

研究论文

α-(2-噻唑基脲基)膦酸二苯酯的合成

李在国;黄润秋;邵瑞链   

  1. 南开大学元素有机化学研究所.天津(300071);南开大学元素有机化学国家重点 实验室
  • 发布日期:1999-10-25

Synthesis of α-(2-thiazolylureido)-alkylphosphonic acid diphenyl esters

Li Zaiguo;Huang Runqiu;Shao Ruilian   

  1. Nankai Univ, Elementoorgan Chem Lab.Tianjin(300071)
  • Published:1999-10-25

报道了一种简便的合成取代脲基膦酸酯的通用的新方法。在二氯甲烷中,三乙胺为缚酸剂的条件下,α-氨基膦酸二苯酯与三聚光气反应形成α-异氰酸基膦酸酯2,2不经分离,直接与2-氨基(苯并)噻唑加成得到α-(2-噻唑基脲基)膦酸二苯酯3,产率55.0%-88.9%。

关键词: 苯并噻唑P, 膦酸酯类, α-取代基, 噻唑P, 氨基膦酸P, 异氰酸酯P, 脲基, 加成反应, 三聚物, 光气

A simple and efficient method for the synthesis of various substituted ureidoalkylphos-phonates was reported. α-(2- Thiazolylureido)-alkylphosphonic acid diphenyl esters(3) were synthesized by the reaction of (substituted) 2-amino (benzo) thiazole with α-isocyanatoalkylphosphonic acid diphenyl esters (2), which were prepared in one-pot by treating α-aminoalkylphosphonic acid diphenyl esters (1) with triphosgene. The yields of 3 are moderate to high (55.0%-88.9%).

Key words: ADDITION REACTION, ALPHA--SUBSTITUENT GROUP, PHOSPHONIC ACID ESTER, TRIMER, THIAZOLE P, PHOSPHOAMIDIC ACID P, CARBAMIDO GROUP, PHOSGENE, ISOCYANATE P, BENZOTHIAZOLE P

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