关键词: 抗癌化疗剂, 核苷, 抑制剂, 氨基磷酸 P, 次黄嘌呤, 抗癌药, 药理

The recent progress of nucleoside analogues as anticancer agents is reviewed. The mechanisms for the action of these nucleoside analogues and drag metabolism are introduced. Especially the inosine 5'- monophosphate dehydrogenase (IMPDH) inhibitors are described. At last the relationship between the structure of nucleoside phosphoramidates and their anticancer activity is discussed.

Key words: nucleoside anticancer agent;NUCLEOSIDE;INHIBITOR;PHOSPHORAMIDIC ACID P, ACETOACETIC ACID P;ANTICARCINOGEN;PHARMACOLOGY;