有机化学 ›› 2003, Vol. 23 ›› Issue (11): 1244-1248. 上一篇    下一篇

研究论文

微波促进的1,3-偶极环加成4β-1,2,3-三唑鬼臼毒素的合成

施建峰;王彦广   

  1. 浙江大学化学系
  • 发布日期:2003-11-25

Solvent-Free Synthesis of 4β-1,2,3-Triazol-1-ylpodophyllotoxins by Microwave-Induced 1,3-Dipolar Cycloaddition of Azides to Alkynes

Shi Jianfeng;Wang Yanguang   

  1. Department of Chemistry, Zhejiang University
  • Published:2003-11-25

在微波作用的无溶剂条件下,由4β-叠鬼臼毒素与炔烃反应,合成了8个含有 1,2,3-三唑的鬼臼毒素衍生物,并用IR, ~1H NMR, MS确定了这些化合物的结构。 该反应操作简单,产率较高,副产物少,同时具有原子经济性。

关键词: 三唑 P, 环加成反应, 鬼臼毒素, 红外分光光度法, 质子磁共振谱法, 质谱法

1, 3-Dipolar cydoaddition of 4β-azidopodophyllotoxins 4 to alkynes under solvent-free microwave irradiation resulted in the corresponding 4β-1,2,3-triazol-l-yl podophy Ho toxins 6~7 in good to excellent yields. The structures of compounds were confirmed by IR, ~1H NMR and MS spectra as well as elemental analysis.

Key words: PYRRODIAZOLE P;CYCLOADDITION REACTION;podophyllotoxin;IR;1HNMR, MS

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