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有机化学
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有机化学 ›› 1989, Vol. 9 ›› Issue (6): 552-554. 上一篇    下一篇

研究论文

2H-苯骈吡喃类化合物的简便合成方法

黄邦洲;朱天民;于学君;金玑珠;吴世晖   

  1. 复旦大学化学系
  • 发布日期:1989-12-25

A convenient route for the synthesis of 2H-1-benzopyranes

HUANG BANGZOU;ZHU TIANMIN;YU XUEJUN;JIN JIZHU;WU SHIHUI   

  • Published:1989-12-25

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458

被引次数

2

本文报道了一种简便合成2H-苯骈吡喃基本骨架的新方法, 并用此法合成了从Ageratum属植物中分离得到的2,2-二甲基-6,7-二甲氧基苯骈吡喃。

关键词: 选择性, 苯并吡喃 P, 加成反应, 合成法, 生物活性物质, 藿香

2H-1-Benzopyrans were synthesized by the reaction of 2-hydroxybenzaldehydes and allyl bromide in the presence of powdered tin. From the reaction of 2-hydroxy-4,5-dimethoxybenzaldehyde and 2-methyl-3-bromo-1-propene the natural product 2,2-dimethyl-6,7-dimethoxybenzopyrane (I), presented in Ageratum houstonianm, was synthesized (yield 50%). The mechanism of reaction which leads to 2H-benzopyranes was suggested.

Key words: SELECTIVITY, BENZOPYRAN P, ADDITION REACTION, SYNTHESIS METHODS, BIOACTIVE SUBSTANCE, AGASTACHE RUGOSA

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