有机化学 ›› 1993, Vol. 13 ›› Issue (2): 175-177. 上一篇    下一篇

研究论文

丙烯基环状氨基甲酸酯的脱羧环合成反应: 机理研究和天然产物合成中的应用

汪嘉林;JOSEPH C. CALABRESE   

  1. 杜邦. 默克药物公司
  • 发布日期:1993-04-25

Decarboxylative cyclization of allylic cyclic carbamates: mechanism studies and applications to the synthesis of natural products^[1]

WANG JIALIN;JOSEPH C. CALABRESE   

  • Published:1993-04-25

研究了通过烯丙基环状氨基甲酸酯的脱环羧化得到2-取代-△^3-哌啶和吡咯烷的机理, 并讨论了应用这一反应于新疆党参碱的全合成。

关键词: 党参宁, 环化, 天然产物, 氨基甲酸酯, 烯丙基, 全合成, 脱羧基化, 党参碱

The mechanism of decarboxylative cyclization of allylic cyclic carbamates leading to 2-substituted △^3-piperidines and -pyrrolidines, as well as its applications to the total synthesis of (-)-codonopsine, are described.

Key words: CARBAMIC ACID ESTER, CYCLIZATION, NATURAL PRODUCTS, ALLYL GROUP, TOTAL SYNTHESIS, DECARBOXYLATION

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