有机化学 ›› 2000, Vol. 20 ›› Issue (1): 1-10.    下一篇

研究论文

催化不对称反应新发展: 不对称活化

丁奎岭;林国强   

  1. 中国科学院上海有机化学研究所.上海(200032)
  • 发布日期:2000-02-25

Recent advances in catalytic asymmetric reactions: Asymmetric activation

Ding Kuiling;Lin Guoqiang   

  1. Shanghai Inst Organ Chem., CAS.Shanghai(200032)
  • Published:2000-02-25

介绍了催化不对称催化反应中的一个新概念-不对称活化(asymmetricactivation)及其研究的最新发展。运用不对称活化策略,一个光学活性的整或者甚至外消旋的催化剂可以被另一种手性活化剂(chiralactivator)选择性的活化,从而催化反应生成非外消旋产物。该方法较不对称活化(asymmetricactivation)方法的优点是被活化的催化剂能够产生较使用光学纯催化剂更高对映体过量的产物。

关键词: 不对称活化, 催化, 手性, 羰基烯, 苯丙烯, 乙醛酸丁酯

A new strategy for asymmetric synthesis, nameld asymmetric activation, is presented and some of its recent advances are reviewed.With asymmetric activation strategy, a chiral or even racemic catalyst may be selectively activated by a chiral activator to yield non-racemic prodlucts. The advantage of this approach over the deactivation strategy is that the activated catalyst can produce angreater enantiometric excess in the products than the enantiomerically pure catalyst can alone.

Key words: CATALYSIS, CHIRALITY, PROPENYL BENZENE

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