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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (01): 72-76. 上一篇    下一篇

研究论文

N-[5-(4-三氟甲基苯基)-1,3,4-噻二唑-2-基]-N′-芳酰基脲的合成、结构及其生物活性

宋新建a,b，王胜a，谭小红b，王子云a,c，汪焱钢*,a   

  1. (a华中师范大学化学学院 武汉 430079)
    (b湖北民族学院化学与环境工程学院 恩施 445000)
    (c周口师范学院化学系 周口 466000)
  • 收稿日期:2006-03-07 修回日期:1900-01-01 发布日期:2006-12-30
  • 通讯作者: 汪焱钢

Synthesis, Structure and Biological Activity of N-[5-(4-Trifluoromethylphenyl)-1,3,4-thiadiazol-2-yl]-N'-aroylureas

SONG Xin-Jiana,b,WANG Shenga,TAN Xiao-Hongb
WANG Zi-Yuna,c,WANG Yan-Gang*,a   

  1. (a College of Chemistry, Central China Normal University, Wuhan 430079)
    (b School of Chemical and Environmental Engineering, Hubei Institute for Nationalities, Enshi 445000)
    (c Department of Chemistry, Zhoukou Normal University, Zhoukou 466000)
  • Received:2006-03-07 Revised:1900-01-01 Published:2006-12-30
  • Contact: WANG Yan-Gang

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通过2-氨基-5-(4-三氟甲基苯基)-1,3,4-噻二唑与芳酰基异氰酸酯反应, 合成了14种新的芳酰基脲, 它们的结构用红外光谱、核磁共振氢谱和元素分析进行了表征, 并且采用X-射线单晶衍射分析方法测定了化合物2l的结构．初步的生物活性试验表明, 部分标题化合物具有优良的植物生长调节活性.

关键词: 芳酰基脲, 生物活性, 1,3,4-噻二唑, 晶体结构, 合成

Fourteen novel aroylureas have been synthesized by the reaction of 2-amino-5-(4-trifluoro- methylphenyl)-1,3,4-thiadiazole with aroyl isocyanates. Their structures were characterized by IR, 1H NMR spectra and elemental analysis, and the structure of 2l was determined by X-ray single crystal diffraction method. The preliminary biological activity tests showed that some title compounds have good activity as plant growth regulator.

Key words: 1,3,4-thiadiazole, biological activity, synthesis, crystal structure, aroyl urea