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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (03): 347-357. 上一篇    下一篇

综述与进展

六甲基磷酰胺在有机合成中的应用

赵夕龙，马宁*   

  1. (天津大学理学院化学系 天津 300072)
  • 收稿日期:2006-01-18 修回日期:2006-06-06 发布日期:2007-02-13
  • 通讯作者: 马宁

Application of Hexamethylphosphoramide to Organic Synthesis

ZHAO Xi-Long,MA Ning*   

  1. (Department of Chemistry, School of Science, Tianjin University, Tianjin 300072)
  • Received:2006-01-18 Revised:2006-06-06 Published:2007-02-13
  • Contact: MA Ning

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2995

被引次数

8

综述了近20年来六甲基磷酰胺(HMPA)作为溶剂对有机反应的显著影响, 并着重总结HMPA所发生的化学反应及其在有机合成中的应用．

关键词: 二甲胺基化, 加成, 催化, 配体, 六甲基磷酰胺, 溶剂

Abstract In this paper the application of hexamethylphosphoramide (HMPA) to organic synthesis has been reviewed on two aspects. Firstly, when HMPA is added to the reation system, it can affect the rate, re-gioselectivity and stereoselectivity of addition or substitution reactions as solvent or cosolvent. Secondly, it can also take part in many reactions, such as dimethylamination, synthesis of chiral catalysts and ligands, addition with carbonyl group, and complexation with metal ions.

Key words: addition, catalyst, solvent, ligand, dimethylamination, hexamethylphosphoramide