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有机化学 ›› 2006, Vol. 26 ›› Issue (07): 967-970. 上一篇    下一篇

研究简报

水介质中N-芳基-N'-(2-苯并呋喃甲酰基)硫脲及1-芳甲酰基-4-(2'-苯并呋喃甲酰基)氨基硫脲的合成

王喜存*，张彰，权正军，王满刚，王芳
李政，杨春燕   

  1. (西北师范大学化学化工学院 甘肃省高分子材料重点实验室 兰州 730070)
  • 收稿日期:2005-08-04 修回日期:2006-01-09 发布日期:2006-07-01
  • 通讯作者: 王喜存

Synthesis of N-Aryl-N'-(2-benzofuroyl)-thioureas and 1-Aroyl-4-(2'-benzofuroyl)-thiosemicarbazides in Aqueous Media

WANG Xi-Cun*,ZHANG Zhang,QUAN Zheng-Jun,WANG Man-Gang
WANG Fang,LI Zheng,YANG Chun-Yan   

  1. (Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering,
    Northwest Normal University, Lanzhou 730070)
  • Received:2005-08-04 Revised:2006-01-09 Published:2006-07-01
  • Contact: WANG Xi-Cun

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苄基三乙基氯化铵(TEBA)存在的水介质中, 2-苯并呋喃甲酰氯、硫氰酸铵与芳胺或芳甲酰肼在室温条件下经一步反应合成N-芳基-N'-(2-苯并呋喃甲酰基)硫脲或1-芳甲酰基-4-(2'-苯并呋喃甲酰基)氨基硫脲, 其中前者尚未见文献报道. 与其它合成方法相比, 该法操作简单、反应条件温和、环境友好.

关键词: 苯并呋喃甲酰基硫脲, 苯并呋喃甲酰基氨基硫脲, 绿色合成, 水

A series of of N-aryl-N'-(2-benzofuroyl)-thioureas and 1-aroyl-4-(2'-benzofuroyl)- thiosemicarbazides were synthesized by the reaction of 2-benzofuroyl chloride with ammonium thiocyanate and arylamine or aroylhydrazine in the presence of benzyltriethylammonium chloride (TEBA) as catalyst via a one-step reaction in aqueous media. This strategy has the advantages of simple operation, mild reaction condition and environmental friendliness.

Key words: 1-aroyl-4-(2'-benzofuroyl)-thiosemicarbazide, water, green synthesis, N-aryl-N'-(2-benzofuroyl)-thiourea