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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (03): 419-423. 上一篇    下一篇

研究论文

无溶剂条件下活性炭固载硫酸催化酮和芳香醛的Cross-Aldol缩合反应

马峰，李立强，郝海娥，苏艳，刘万毅   

  1. (宁夏大学化学化工学院 宁夏大学能源化工重点实验室 银川 750021)
  • 收稿日期:2009-07-05 修回日期:2009-09-03 发布日期:2010-03-28
  • 通讯作者: 刘万毅 E-mail:liuwy@nxu.edu.cn
  • 基金资助:

    国家973前期预研(No. 2006CB708606)资助项目

Activated Carbon Supported Sulfuric Acid as an Efficient Catalyst for Cross-Aldol Condensation of Ketones with Aromatic Aldehydes under Solvent-Free Conditions

Ma Feng,Li Liqiang,Hao Haie,Su Yan,Liu Wanyi   

  1. (Key Laboratory of Energy Sources ＆ Engineering, School of Chemistry and Chemical Engineering,
    Ningxia University, Yinchuan 750021)
  • Received:2009-07-05 Revised:2009-09-03 Published:2010-03-28

PDF

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被引次数

30 | 7

以活性炭固载硫酸(acsa)为催化剂, 在无溶剂条件下催化酮和芳香醛的Cross-Aldol反应, 成功合成了16个相应的α, β不饱和缩合产物, 反应时间30～100 min, 产率可达65%～94%. 该方法不仅反应时间短, 产率高, 催化剂可以重复利用, 后处理简单, 而且还对环境友好. 产物经熔点, IR, 1H NMR, 13C NMR确证.

关键词: 无溶剂, Cross-Aldol缩合, 活性炭固载硫酸, 酮, 芳香醛

Aromatic aldehydes underwent cross-aldol condensation with ketones in the presence of activated carbon supported sulfuric acid (acsa) under solvent-free conditions to afford 16 corresponding α,β-unsaturated aldol products in reaction time of 30～100 min, and the good yields from 65% to 94%. This method provides a simple, fast and clean reaction, using a small quantity of catalyst and a simple workup procedure. The catalyst could be reused. The structures of the products were characterized by IR, 1H NMR and 13C NMR techniques.

Key words: solvent-free, cross-aldol condensation, acsa, ketone, aromatic aldehyde