有机化学 ›› 2013, Vol. 33 ›› Issue (05): 877-890.DOI: 10.6023/cjoc201210013 上一篇    下一篇

综述与进展

铜催化C—N, C—O偶联反应的研究进展

成宜娟, 孙丽萍   

  1. a 江苏省药物分子设计与成药性优化重点实验室 中国药科大学 南京 210009;
    b 中国药科大学药学院药物化学教研室 南京 210009
  • 收稿日期:2012-10-17 修回日期:2013-01-20 发布日期:2013-01-25
  • 通讯作者: 孙丽萍,chsunlp@yahoo.com.cn E-mail:chsunlp@yahoo.com.cn
  • 基金资助:

    国家自然科学基金(No. 21172265)和江苏省高校“青蓝工程”资助项目.

Research Progress towards Copper-Catalyzed Coupling Reactions for C—N Bonds and C—O Bonds

Cheng Yijuan, Sun Liping   

  1. a Jiangsu Key Laboratory of Drug Design & Optimization, China Pharmaceutical University, Nanjing 210009;
    b Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009
  • Received:2012-10-17 Revised:2013-01-20 Published:2013-01-25
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21172265) and the “Qinglan Project” of Jiangsu Province.

C—N, C—O键偶联是有机合成中的一类重要反应, 铜催化的偶联反应是该类化学键形成中的主要手段之一, 相比钯等过渡金属, 金属铜具有低毒、廉价、反应条件温和等优点. 按照所形成化合物的结构类型综述了铜催化C—N, C—O键偶联反应的最新研究进展.

关键词: C—N偶联反应, C—O偶联反应, 铜催化, 进展

C—N and C—O coupling reaction is a significant procedure in organic synthesis and copper-catalyzed coupling reaction is one of the predominant methods. Copper has advantages of low-toxicity, cheap price and gent reaction conditions comparing to other transition metals such as palladium. In this review, the recent progress in copper-catalyzed C—N and C—O coupling reactions is reviewed according to the structure categories of compounds.

Key words: C—N coupling reaction, C—O coupling reaction, copper-catalyzed, progress