有机化学 ›› 2014, Vol. 34 ›› Issue (12): 2523-2528.DOI: 10.6023/cjoc201401038 上一篇    下一篇

研究论文

缩醛与吲哚或苯并呋喃的烷基化反应

刘宁宁, 杨玲, 杨蓓, 王金棒, 陈雪, 武钦佩   

  1. 北京理工大学化工与环境学院 北京 100081
  • 收稿日期:2014-06-23 修回日期:2014-08-10 发布日期:2014-08-26
  • 通讯作者: 武钦佩 E-mail:qpwu@bit.edu.cn
  • 基金资助:

    国家自然科学基金(No.21172019)资助项目.

Alkylation of Indole and Benzofuran with Acetals

Liu Ningning, Yang Ling, Yang Bei, Wang Jinbang, Chen Xue, Wu Qinpei   

  1. School of Chemical Engineering and Environments, Beijing Institute of Technology, Beijing 100081
  • Received:2014-06-23 Revised:2014-08-10 Published:2014-08-26
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21172019).

苯并呋喃衍生物和吲哚衍生物广泛存在于天然产物中, 普遍具有生物活性. 缩醛是被频繁使用的羰基保护基团. 在TMSOTf和三甲基吡啶作用下, 芳香基和烷基缩醛都可以直接与苯并呋喃或者吲哚发生烷基化反应; 缩醛的两个烷氧基被苯并呋喃或者吲哚取代生成双苯并呋喃或双吲哚甲烷衍生物, 与苯并呋喃相比, 吲哚烷基化反应的得率较高. 环状缩醛、含有氨基的缩醛和丙酮缩二甲醇也可以直接发生烷基化反应, 反应条件温和. 缩醛的一个烷氧基被吲哚取代的产物及其被转化为双取代产物的实验结果为反应机理提供了证据.

关键词: 苯并呋喃, 吲哚, 缩醛, 烷基化

Benzofuran derivatives and bisindolylmethane derivatives are widely present in natural products, and have significant biological activity. Acetals were demonstrated to be efficient alkylating agents in the presence of TMSOTf and 2,4,6-collidine. Bisbenzofuranmethane and bisindolylmethane derivatives were easily obtained via direct alkylation of benzofurnan or indole with a series of acetals including amino, cyclic, acetone, aryl and alkyl acetals. The reaction mechanism was proposed.

Key words: benzofuran, indole, acetal, alkylation