有机化学 ›› 2024, Vol. 44 ›› Issue (9): 2898-2905.DOI: 10.6023/cjoc202412024 上一篇    下一篇

研究论文

t-BuOK/DMF促进的通过自由基过程实现吲哚酮的C-3位硫化反应

王丽丽, 张洲, 王廷良, 王兴兰, 毛远湖, 张吉泉*()   

  1. 贵州医科大学药学院 贵州省化学合成药物研发利用工程技术研究中心 贵阳 561113
  • 收稿日期:2024-03-11 修回日期:2024-04-18 发布日期:2024-05-10
  • 通讯作者: 张吉泉
  • 基金资助:
    国家自然科学基金(22267003); 贵州省自然科学基金(ZK[2023]305); 贵州省自然科学基金(ZK[2024]170); 贵州省优秀青年科技人才计划(YQK[2023]030); 贵州医科大学优秀青年人才计划([2022]102)

t-BuOK/DMF-Promoted C-3 Sulfuration of Oxindoles via a Radical Process

Lili Wang, Zhou Zhang, Tingliang Wang, Xinglan Wang, Yuanhu Mao, Jiquan Zhang()   

  1. Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, College of Pharmacy, Guizhou Medical University, Guiyang 561113
  • Received:2024-03-11 Revised:2024-04-18 Published:2024-05-10
  • Contact: Jiquan Zhang
  • Supported by:
    National Natural Science Foundation of China(22267003); Guizhou Provincial Basic Research Program (Natural Science)(ZK[2023]305); Guizhou Provincial Basic Research Program (Natural Science)(ZK[2024]170); Guizhou Provincial Excellent Young Talents Plan(YQK[2023]030); Excellent Young Talents Plan of Guizhou Medical University([2022]102)

发展了一种高效的吲哚酮的C-3位直接硫化反应. 通过使用二硫化物作为硫化试剂, t-BuOK/N,N-二甲基甲酰胺(DMF)作为催化剂, 一系列吲哚酮的C-3位硫化产物被成功合成. 该方法具有较高的原子经济性、环境友好且底物适应范围广.

关键词: 吲哚酮, 二硫化物, 硫化反应, 自由基

An efficient C-3 sulfuration of oxindoles has been developed. Using disulfide as the sulfurating agent, a wide range of sulfurated oxindoles have been synthesized under t-BuOK/N,N-dimethylformamide (DMF) promoted conditions. The present method is highly atom economic, environmentally friendly and tolerated a broad scope of substrates.

Key words: oxindole, disulfide, sulfuration, radical