有机化学 ›› 2014, Vol. 34 ›› Issue (10): 2083-2089.DOI: 10.6023/cjoc201403034 上一篇    下一篇

研究论文

氨基脲催化下碳亲核试剂和氮亲核试剂对查尔酮的Michael加成反应

程贺龙, 高玉华, 聂士鹏, 陆鸿飞   

  1. 江苏科技大学生物与化学工程学院 镇江 212003
  • 收稿日期:2014-03-14 修回日期:2014-05-08 发布日期:2014-06-03
  • 通讯作者: 陆鸿飞 E-mail:zjluhf1979@hotmail.com

Michael Addition of Carbon and Nitrogen Nucleophiles with Chalcone Catalyzed by Semicarbazide

Cheng Helong, Gao Yuhua, Nie Shipeng, Lu Hongfei   

  1. a. School of Biology and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003
  • Received:2014-03-14 Revised:2014-05-08 Published:2014-06-03

以查尔酮、丙二酸酯、丙二腈、苯胺为原料,水为溶剂,苯丙氨酸脲化合物为催化剂,三氟甲磺酸为助剂60 ℃下反应,高产率得到Michael加成产物. 该方法具有催化剂合成简单、环境友好等优点.

关键词: 查尔酮, 丙二酸酯, 苯丙氨酸脲化合物, Michael加成

An efficient Michael addition of chalcone and malonate, malononitrile, aniline catalyzed by phenylalanine-urea in water has been disclosed at 60 ℃ with trifluoromethanesulfonate, affording the corresponding adducts in good yields, while the catalyst was easy to handle up and the solvent was environmentally friendly.

Key words: chalcone, malonate, phenylalanine-urea, Michael addition reaction