微波技术在钯催化Suzuki-Miyaura交叉偶联反应中的应用研究进展

doi:10.6023/cjoc201507008

摘要/Abstract

与传统的加热方图式相比, 微波加热具有加热速度快、热效率高、节约能源、洁净、操作简单等优点, 已成为重要的有机合成工具之一. 钯催化的Suzuki-Miyaura交叉偶联反应提供了一种合成各种联芳烃的温和方法, 具有较好的选择性, 受到了合成化学家的广泛关注. 综述了近年来微波技术在钯催化的Suzuki-Miyaura交叉偶联反应中的应用研究进展, 包括多种反应体系, 并对其在天然产物和生物活性分子合成中的应用作简要概述.

关键词: 微波技术, 钯, Suzuki-Miyaura交叉偶联反应, 催化

Compared with conventional heating, microwave heating is one of the most useful tools in organic synthesis because of its obviously advantages of fast heating, thermal efficiency, saving energy, clean, and easy operation. Palladium catalyzed Suzuki-Miyaura cross-coupling reaction could tolerate a broad range of functional groups with high stereoselectivity to provide a mild method in preparation of kinds of substituted biaryls. In this paper, the recent research results about the microwave technique applied in Suzuki-Miyaura cross-coupling reaction are reviewed, involving various reaction systems. The applications of the methodology on the synthesis of natural products and bioactive molecules have also been introduced.

Key words: microwave technique, palladium, Suzuki-Miyaura cross-coupling reaction, catalyze

引用此文

李清寒, 丁勇, 张刚, 张震, 莫松. 微波技术在钯催化Suzuki-Miyaura交叉偶联反应中的应用研究进展[J]. 有机化学, 2016, 36(1): 83-104.

Li Qinghan, Ding Yong, Zhang Gang, Zhang Zhen, Mo Song. Advance on Applications of Microwave Technique in Palladium- Catalyzed Suzuki-Miyaura Cross-Coupling Reaction[J]. Chin. J. Org. Chem., 2016, 36(1): 83-104.

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