有机化学 ›› 2016, Vol. 36 ›› Issue (10): 2499-2503.DOI: 10.6023/cjoc201604021 上一篇    下一篇

研究简报

氯化锌催化酚与异戊烯基溴的串联反应合成苯并吡喃化合物

刘子召, 徐凡   

  1. 苏州大学材料与化学化工学部 苏州 215123
  • 收稿日期:2016-04-11 修回日期:2016-05-11 发布日期:2016-06-02
  • 通讯作者: 徐凡,E-mail:xufan@suda.edu.cn E-mail:xufan@suda.edu.cn
  • 基金资助:

    国家自然科学基金(No.21272168)资助项目.

Synthesis of Chromans via Domino Reaction of Phenols with Prenyl Bromide Catalyzed by Zinc Chloride

Liu Zizhao, Xu Fan   

  1. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123
  • Received:2016-04-11 Revised:2016-05-11 Published:2016-06-02
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.21272168).

苯并吡喃骨架存在于许多天然及合成的生物活性物质中,因此发展其高效合成方法极具实用价值.本工作以氯化锌为催化剂催化酚与异戊烯基溴发生傅克/氢烷氧化串联反应,高效合成了一系列苯并吡喃化合物.该方法所用催化剂简单易得,催化剂用量少,反应条件温和,为苯并吡喃类化合物的合成提供了一种高效且实用的路径.

关键词: 苯并吡喃, 氯化锌, 催化, 异戊烯基溴

Chroman skeleton exists in many natural and synthetic biologically active materials. A highly efficient method for the synthesis of chromans via reaction of phenols with prenyl bromide catalyzed by zinc chloride is described, which provides a practical process to afford this type of biologically important compounds in good yields using commercially available and inexpensive catalyst under mild conditions.

Key words: chroman, zinc chloride, catalysis, prenyl bromide