有机化学 ›› 2017, Vol. 37 ›› Issue (4): 925-935.DOI: 10.6023/cjoc201611009 上一篇    下一篇

研究论文

铟粉促进下“一锅法”合成三氟甲基高烯丙基酰肼化合物

李军, 杨天宇, 张怀远, 黄丹凤, 王克虎, 苏瀛鹏, 胡雨来   

  1. 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2016-11-04 修回日期:2016-12-26 发布日期:2017-01-10
  • 通讯作者: 黄丹凤, 胡雨来 E-mail:huyl@nwnu.edu.cn;huangdf@nwnu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21262031,21462037)资助项目.

One-Pot Synthesis of Trifluoromethylated Homoallylic N-Acylhydrazines Promoted by Indium Powder

Li Jun, Yang Tianyu, Zhang Huaiyuan, Huang Danfeng, Wang Kehu, Su Yingpeng, Hu Yulai   

  1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2016-11-04 Revised:2016-12-26 Published:2017-01-10
  • Contact: 10.6023/cjoc201611009 E-mail:huyl@nwnu.edu.cn;huangdf@nwnu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21262031, 21462037).

探索了铟粉促进下,三氟乙醛甲基半缩醛或三氟甲基苯乙酮与酰肼和烯丙基溴的“一锅法”反应,高产率地得到了一系列三氟甲基高烯丙基酰肼类化合物. 该方法使用价廉易得的三氟乙醛甲基半缩醛或三氟苯乙酮作为三氟甲基合成砌块,具有反应条件温和、产率高、操作简单等优点.

关键词: 一锅法, 铟粉, 三氟乙醛甲基半缩醛, 三氟苯乙酮, 酰肼, 三氟甲基高烯丙基酰肼

An one-pot reaction of trifluoroacetaldehyde methyl hemiacetal or trifluoroketones, acylhydrazines and allyl bromide promoted by indium powder is reported, and a series of trifluoromethylated homoallylic N-acylhydrazines were obtained with good to excellent yields. The features of this process include readily available starting materials as trifluoromethyl building blocks, mild conditions and easy operation.

Key words: one-pot, indium powder, trifluoroacetaldehyde methyl hemiacetal, trifluoroketones, arylacylhydrazines, trifluoromethylated homoallylic N-acylhydrazines