有机化学 ›› 2017, Vol. 37 ›› Issue (4): 810-823.DOI: 10.6023/cjoc201611032 上一篇    下一篇

综述与进展

石松生物碱集成合成的研究进展

肖春霞a, 曹林a, 王佳a, 苗银龙a, 范华芳a,b   

  1. a. 西北农林科技大学 陕西省天然产物化学生物学重点实验室 杨凌 712100;
    b. 中国科学院上海有机化学研究所 中国科学院天然产物有机合成化学重点实验室 上海 200032
  • 收稿日期:2016-11-24 修回日期:2016-12-24 发布日期:2017-01-17
  • 通讯作者: 范华芳 E-mail:fhf@nwafu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21403169,21502153)、中国博士后科学基金(No.2013M532084)、中央高校基本科研业务费(No.2452015079)资助项目.

Advances in the Collective Synthesis of Lycopodium Alkaloids

Xiao Chunxiaa, Cao Lina, Wang Jiaa, Miao Yinlonga, Fan Huafanga,b   

  1. a. Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling 712100;
    b. Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2016-11-24 Revised:2016-12-24 Published:2017-01-17
  • Contact: 10.6023/cjoc201611032 E-mail:fhf@nwafu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21403169, 21502153), the Postdoctoral Science Foundation of China (No. 2013M532084) and the Chinese Universities Scientific Fund (No. 2452015079).

鉴于同一家族天然产物在化学结构和生物合成途径上的相关性,2011年MacMillan等提出利用相同或相似的关键中间体快速高效合成天然产物家族化合物的集成合成策略,近年来该策略被应用于多个家族天然产物的合成中. 石松生物碱是一类结构奇特且复杂多样的生物碱,部分成员化合物表现出良好的生物活性. 综述了国内外有机合成化学家对石松生物碱家族化合物的集成合成研究进展.

关键词: 石松生物碱, 天然产物, 全合成, 集成合成

In view of the relevance between chemical structures and biosynthetic pathways of compounds that belong to the same family of natural products, MacMillan et al. (2011) proposed a strategy for the rapid and efficient synthesis of natural product within a family from a common intermediate or a group of similar intermediates, which is termed as collective synthesis. In recent years, this strategy has been applied for the synthesis of multiple family of natural products. Lycopodium alkaloids are a class of structurally diverse alkaloids, and many of them exhibiting good biological activity. In this review, the progress in the collective synthesis of Lycopodium alkaloids is summarized.

Key words: Lycopodium alkaloids, natural products, total synthesis, collective synthesis