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有机化学 ›› 2017, Vol. 37 ›› Issue (10): 2763-2766.DOI: 10.6023/cjoc201705035 上一篇    下一篇

研究简报

海南暗罗根克罗烷型二萜化学成分研究

李小宝a, 陈光英a, 邵泰明a,b, 宋小平a, 韩长日a,b, 余章昕a   

  1. a 海南师范大学化学与化工学院 热带药用植物化学教育部重点实验室 海口 571158;
    b 海南省药食同源植物资源重点实验室 海南科技职业学院化学与材料工程学院 海口 571126
  • 收稿日期:2017-05-23 修回日期:2017-06-10 发布日期:2017-06-23
  • 通讯作者: 韩长日 E-mail:hchr116@126.com
  • 基金资助:

    国家自然科学基金（Nos.81160391，21362009，81360478）、国家国际科技合作专项（No.2014DFA40850）、创新发展团队（No.IRT-16R19）、海南省自然科学基金创新研究团队（No.2016CXTD007）及海南省自然科学基金（No.20162031）资助项目.

Clerodane Diterpenes from the Roots of Polyalthia laui

Li Xiaobaoa, Chen Guangyinga, Shao Taimingaa,b, Song Xiaopinga, Han Changria,b, Yu Zhangxina   

  1. a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158;
    b Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, School of Chemical and Material Engineering, Hainan Institute of Science and Technology, Haikou 571126
  • Received:2017-05-23 Revised:2017-06-10 Published:2017-06-23
  • Contact: 10.6023/cjoc201705035 E-mail:hchr116@126.com
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.81160391,21362009,81360478),the International S&T Cooperation Program of China (No.2014DFA40850),the Program for Innovative Research Team in University (No.IRT-16R19),the Hainan Provincal Natural Science Foundation of Innovatie Research Team Project (No.2016CXTD007) and the Natural Science Foundation of Hainan Province (No.20162031).

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对海南暗罗根化学成分进行系统研究，分离得到5个克罗烷型二萜类化合物.根据它们的NMR和HRMS数据，鉴定它们的结构分别为：（4→2）重排-2，13-二甲酰基-克罗烷-2，12E-二双键-15-甲酯（1）、克罗烷-3，12E-二双键-15，16-二甲酸（2）、14，15-降二碳克罗烷-3-双键-2，13-二酮（3）、克罗烷-3，13Z-二双键-15，16-内酯（4）、16-羟基克罗烷-3，13Z-二双键-15，16-内酯（5）.其中化合物1~2为新化合物.化合物1~5的体外细胞毒活性筛选结果表明，它们对4种肿瘤细胞株（Hela、A549、MCF-7和HL-60）均显示出了一定的体外生长抑制活性，其IC50值范围为13.22~37.16 μmol/L.

关键词: 海南暗罗, 克罗烷型二萜, 细胞毒活性

Five clerodane diterpenes were isolated from the roots of Polyalthia laui during a systematic phytochemical investigation. Their structures were elucidated by the NMR and HRMS data as methyl (4→2)-abeo-2,13-diformyl-cleroda-2,12E-dien-15-ate (1), (E)-ent-cleroda-3,12-diene-15,16-dioic acid (2), 14,15-dinorclerod-3-ene-2,13-dione (3), solidagolactone (4), and 16-hydroxy-3,13Z-kolavadien-16,15-olide (5). Among them, compounds 1~2 are new clerodane diterpenes. Biological evaluation of compounds 1~5 against human Hela, A549, MCF-7 and HL-60 human cancer cell lines showed that all com-pounds displayed moderate cytotoxicities against various human cancer cell lines with IC50 ranged from 13.22 to 37.16 μmol/L.

Key words: Polyalthia laui, clerodane diterpenes, cytotoxicities