过渡金属催化的成胍反应高效构建胍类衍生物

doi:10.6023/cjoc201801037

摘要/Abstract

胍及其衍生物是一类很重要的含氮有机化合物，在医药、工农业中应用非常广泛.胍类化合物的合成最先通过各种胍基化试剂制得，近年来逐渐转向由胺与碳二亚胺经合适的催化剂直接制备成胍.系统综述了近十多年过渡金属催化胺与碳二亚胺的成胍反应直接构建非环胍和环状胍的催化机理、反应体系、底物范围及成胍产物的结构特点等.

关键词: 成胍反应, 胍, 胺, 碳二亚胺

Guanidine derivatives are an important class of nitrogen-containing organic compounds, which are widely used in various pharmaceuticals, agrochemicals, sweeteners, explosives, and so on. Although classical methods for the synthesis of guanidines are established, there are still many fatal shortcomings which need to be resolved. In recent years, it has been gradually turned to the direct catalytic guanylation reaction of amines with carbodiimides. In this paper, the recent progress in transition-metal-catalyzed guanylation reaction of amines with carbodiimides to construct acyclic or cyclic guanidines based on the catalytic reaction mechanism, reaction system, the scope of substrates, etc. is reviewed.

Key words: guanylation reaction, guanidines, amines, carbodiimides

引用此文

王连军, 迟樾, 张文雄, 席振峰. 过渡金属催化的成胍反应高效构建胍类衍生物[J]. 有机化学, 2018, 38(6): 1341-1349.

Wang Lianjun, Chi Yue, Zhang Wenxiong, Xi Zhenfeng. Transition-Metal-Catalyzed Guanylation Reaction of Amines with Carbodiimides Constructing Guanidines[J]. Chin. J. Org. Chem., 2018, 38(6): 1341-1349.

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