通过羧酸与异硫氰酸酯的反应直接构筑大位阻与缺电子仲酰胺

doi:10.6023/cjoc201801049

有机化学 ›› 2018, Vol. 38 ›› Issue (7): 1740-1748.DOI: 10.6023/cjoc201801049 上一篇下一篇

研究论文

通过羧酸与异硫氰酸酯的反应直接构筑大位阻与缺电子仲酰胺

谭家希, 郭也, 曾飞, 陈观荣, 谢龙勇, 何卫民

湖南省银杏工程技术研究中心湖南科技学院永州 425100

收稿日期:2018-01-31 修回日期:2018-03-18 发布日期:2018-03-29
通讯作者: 何卫民 E-mail:weiminhe2016@yeah.net
基金资助:
国家自然科学基金（Nos.21602055，21302048）、湖南省高校创新团队（No.2012-318）、湖南省教育厅重点建设学科资助项目.

Synthesis of Sterically Hindered and Electron-Deficient Secondary Amides from Unactivated Carboxylic Acids and Isothiocyanates

Tan Jiaxi, Guo Ye, Zeng Fei, Chen Guanrong, Xie Longyong, He Weimin

Hunan Provincial Engineering Research Center for Ginkgo biloba, Hunan University of Science and Engineering, Yongzhou 425100

Received:2018-01-31 Revised:2018-03-18 Published:2018-03-29
Contact: 10.6023/cjoc201801049 E-mail:weiminhe2016@yeah.net
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21602055, 21302048), the Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province (No. 2012-318) and the Construct Program of the Key Discipline in Hunan Province.

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1. 通过羧酸与异硫氰酸酯的反应直接构筑大位阻与缺电子仲酰胺.PDF(1479KB)

摘要/Abstract

以商业可获得的羧酸和异硫氰酸酯为原料，建立了一种温和、通用、高效的直接合成酰胺化合物的新方法.该方法避免了当量偶联试剂和金属催化剂的使用，特别适合于合成其他常规方法不易合成的大位阻和缺电子仲酰胺化合物.

关键词: 酰胺, 羧酸, 异硫氰酸酯, 合成方法学, 缺电子酰胺

A mild, general and efficient method for the direct synthesis of diverse amides from commercially available carboxylic acids and isothiocyanates has been developed. The strategy does not require stoichiometric amounts of coupling reagents or metal catalysts, and is especially for sterically hindered and electron-deficient secondary amides, which are otherwise challenging to synthesize.

Key words: amides, carboxylic acids, isothiocyanates, synthetic methods, electron-deficient amides

引用此文

谭家希, 郭也, 曾飞, 陈观荣, 谢龙勇, 何卫民. 通过羧酸与异硫氰酸酯的反应直接构筑大位阻与缺电子仲酰胺[J]. 有机化学, 2018, 38(7): 1740-1748.

Tan Jiaxi, Guo Ye, Zeng Fei, Chen Guanrong, Xie Longyong, He Weimin. Synthesis of Sterically Hindered and Electron-Deficient Secondary Amides from Unactivated Carboxylic Acids and Isothiocyanates[J]. Chin. J. Org. Chem., 2018, 38(7): 1740-1748.

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通过羧酸与异硫氰酸酯的反应直接构筑大位阻与缺电子仲酰胺

Synthesis of Sterically Hindered and Electron-Deficient Secondary Amides from Unactivated Carboxylic Acids and Isothiocyanates

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