有机化学 ›› 2019, Vol. 39 ›› Issue (11): 3183-3189.DOI: 10.6023/cjoc201904002 上一篇    下一篇

研究论文

3-乙/芳酰乙酰基吲哚的水相合成

胡小宇, 于海丰*(), 王文举*(), 姜思傲, 刘奇, 何洁   

  1. 白城师范学院化学学院 吉林白城 137000
  • 收稿日期:2019-04-03 发布日期:2019-07-09
  • 通讯作者: 于海丰,王文举 E-mail:yuhf68105@sina.com;wangwj3309@126.com
  • 基金资助:
    吉林省教育厅十三五计划科技(2016037)

Synthesis of 3-Ethanoyl/Aroylacetylindoles in Water

Hu Xiaoyu, Yu Haifeng*(), Wang Wenju*(), Jiang Siao, Liu Qi, He Jie   

  1. a College of Chemistry, Baicheng Normal University, Baicheng, Jilin 137000
  • Received:2019-04-03 Published:2019-07-09
  • Contact: Yu Haifeng,Wang Wenju E-mail:yuhf68105@sina.com;wangwj3309@126.com
  • Supported by:
    the Foundation of Science and Technology Research Projects of the 13th Five-Year Plan of Jilin Provincial Department of Education(2016037)

探讨了4-十二烷基苯磺酸(DBSA)催化的β-乙硫基-β-吲哚基-αβ-不饱和酮(1)的水相水解反应,实现了3-乙/芳酰乙酰基吲哚(2)的水相合成.研究表明,在回流和10 mol% DBSA存在下,1有效地发生水相水解反应,高产率合成产物2.

关键词: 水相反应, 水解反应, 3-乙酰乙酰基吲哚, β-乙硫基-β-吲哚基-α, β-不饱和酮

4-Dodecylbenzenesulfonic acid (DBSA) catalyzed hydrolysis reaction of β-ethylthio-β-indolyl-α, β-unsaturated ketones (1) in water to yield 3-ethanoyl/aroylacetylindoles (2) was studied. It showed that the hydrolysis of 1 in water smoothly occurred in the presence of 10 mol% DBSA in reflux water, and 2 was obtained in excellent yield.

Key words: aqueous reaction, hydrolysis reaction, 3-acetoacetylindole, β-ethylthio-β-indolyl-α, β-unsaturated ketone