有机化学 ›› 2020, Vol. 40 ›› Issue (7): 1891-1900.DOI: 10.6023/cjoc202003019 上一篇    下一篇

综述与进展

N-磺基脒类化合物合成研究进展

郑茜茜, 刘云云, 万结平   

  1. 江西师范大学化学化工学院 南昌 330022
  • 收稿日期:2020-03-08 修回日期:2020-04-01 发布日期:2020-04-13
  • 通讯作者: 刘云云, 万结平 E-mail:chemliuyunyun@jxnu.edu.cn;wanjieping@jxnu.edu.cn
  • 基金资助:
    国家自然科学基金(No.21861019)资助项目.

Advances in the Synthesis of N-Sulfonyl Amidines

Zheng Xixi, Liu Yunyun, Wan Jie-Ping   

  1. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022
  • Received:2020-03-08 Revised:2020-04-01 Published:2020-04-13
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21861019).

脒类化合物因其独特的偕二氮结构,在合成含氮化合物方面具有重要作用.作为脒类化合物中独特的一类,N-磺基脒类化合物更是多种重要有机合成反应的关键中间体,在现代有机合成中占有举足轻重的位置.基于这一背景,对N-磺基脒类化合物的合成进展进行了综述.依据反应特点,分别基于胺氧化酰化反应、炔-叠氮-胺三组分反应、烯胺碳-碳键官能化、酰胺活化以及其它相关的反应等方面的研究进展进行介绍,以期为相关领域的研究工作提供指导作用.

关键词: N-磺基脒, 合成, 胺氧化, 酰胺活化, 三组分, 烯胺反应

Due to the special gem-nitrogen structure, amidines are important compounds in the synthesis of nitrogen contaning products. As a class of featured amidines, the N-sulfonyl amidines are key intermediates in a number of pivatol organic syntheses, and thus ocuppy significant position in modern organic synthesis. In this context, the research advances on the synthesis of N-sulfonyl amidines are herein reviewed. Based on the key reaction features, the introduction covers the synthetic methods of enamination by tertiary enamine oxidation, amide activation, akyne-azide-amine three-component reaction, enamine carbon-carbon bond functionalization and other related reactions. It is expected that this review will provide guidelines for the reasearch work in related areas.

Key words: N-sulfonyl amidine, synthesis, amine oxidation, amide activation, three-component, enamine reaction