有机化学 ›› 2020, Vol. 40 ›› Issue (7): 2142-2147.DOI: 10.6023/cjoc202003032 上一篇    下一篇

研究简报

N-碘代丁二酰亚胺(NIS)/K2S2O8促进烯酰胺的自偶联反应构建含氮原子的季碳中心

周小强a,b, 闫浩b,c, 王秋亚a   

  1. a 渭南师范学院化学与材料学院 陕西渭南 714099;
    b 兰州大学功能有机分子化学国家重点实验室 兰州 730000;
    c 陕西中医药大学药学院 陕西咸阳 712046
  • 收稿日期:2020-03-12 修回日期:2020-03-29 发布日期:2020-04-17
  • 通讯作者: 周小强 E-mail:zhouxq2017@163.com
  • 基金资助:
    陕西省科技厅自然科学基础研究基金(No.2019JQ-902)、陕西省教育厅自然科学专项研究基金(No.19JK0287)和渭南师范学院博士科研启动基金(Nos.18ZRRC05,17ZRRC04)资助项目.

N-Iodo-succininide (NIS)/K2S2O8 Initiated Self-Coupling of Enamides to Nitrogen-Containing Quaternary Carbon Centers

Zhou Xiaoqianga,b, Yan Haob,c, Wang Qiuyaa   

  1. a College of Chemistry and Material, Weinan Normal University, Weinan, Shaanxi 714099;
    b State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000;
    c College of pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046
  • Received:2020-03-12 Revised:2020-03-29 Published:2020-04-17
  • Supported by:
    Project supported by the Natural Science Basic Research Program of Shaanxi Province (No. 2019JQ-902), the Scientific Research Program Funded by Shaanxi Provincial Education Department (No. 19JK0287), and the Scientific Research Foundation of Weinan Normal University (Nos. 18ZRRC05, 17ZRRC04).

报道了一种N-碘代丁二酰亚胺(NIS)/K2S2O8促进的烯酰胺自偶联反应构建C—C键的方法.这种无过渡金属催化的自由基反应具有环境友好和原子经济性高的显著优势,为合成含氮原子的季碳中心结构骨架提供了一种实用方法.

关键词: 季碳中心骨架, 烯酰胺, C—C键构建, 碘化物, 自由基加成, 无过渡金属

N-Iodo-succininide (NIS)/K2S2O8 initiated C-C bond formation reaction through self-coupling of enamides has been reported. The environmental friendliness and high atom-economy of this transition-metal free radical pathway offers a useful and attractive strategy to nitrogen-containing quaternary carbon centers.

Key words: quaternary carbon centers, enamides, C-C bond formation, iodide, radical addition, transition-metal free