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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (4): 423-425. 上一篇    下一篇

研究简报

3,13-二羟基-1,5,8,11,15,18-六氮杂环二十烷的合成研究

梁峰, 吴成泰*   

  1. 武汉大学化学系 武汉 430072
  • 收稿日期:2002-12-08 修回日期:2003-10-08 接受日期:2003-10-08 发布日期:2022-09-19
  • 基金资助:
    国家自然科学基金(No. 29972034)资助项目

A Practical Synthesis of Hydroxyl-Substituted Macrocyclic Hexaa mines

LIANG, Feng, WU, Cheng-Tai*   

  1. Department of Chemistry, Wuhan University, Wuhan 430072
  • Received:2002-12-08 Revised:2003-10-08 Accepted:2003-10-08 Published:2022-09-19
  • Contact: *E-mail: chemoliangf@yahoo.com.cn; Fax: +86(27)87647617.

PDF

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尝试了三种制备3,13-二羟基-1,5,8,11,15,18-六氮杂环二十烷(5)的方法.实验结果表明1,3-二氯-2-丙醇(1)与N-对甲苯磺酰基-二乙烯三胺(2)在醇钠条件下制备5的方法简便可行,易于纯化,收率较高.

关键词: 缩合, 环合, 大环多胺

Three methods were employed to synthesize title compound 3,13-dihydroxyl-1,5,8,11,15,18-hexaaza-cyclicamines (5). A detailed study of the preparation of [2+2] condensation product 5 was made by means of the reaction of 1,3-dichloro-2-propanol (1) with N-tosyl diethylenetriamine (2). The reported synthesis procedure is simple and convenient, and the yield was raised. The product waseasily isolated and purified.

Key words: condensation, cyclization, macrocyclic polyamines