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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (3): 315-318. 上一篇    下一篇

研究简报

新型吡啶类苯并咪唑衍生物的合成

戴桂元*, 刘德龙, 王苏惠, 刘蕴   

  1. 徐州师范大学化学系 徐州 221116
  • 收稿日期:2003-06-02 修回日期:2003-07-31 接受日期:2003-09-10 发布日期:2022-09-20
  • 基金资助:
    国家自然科学基金(No. 29872011)资助项目

Syntheses of Novel Pyridine-Type Derivatives of Benzimidazole

DAI, Gui-Yuan*, LIU, De-Long, WANG, Su-Hui, LIU, Yun   

  1. Department of Chemistry, Xuzhou Normal University, Xuzhou 221116
  • Received:2003-06-02 Revised:2003-07-31 Accepted:2003-09-10 Published:2022-09-20
  • Contact: *E-mail: orgsyn@mail.hbu.edu.cn; Fax: 0312-5079525.

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合成了一系列取代吡啶亚甲基硫代苯并咪唑类衍生物,并在过氧乙酸的氧化下得到其相应的亚砜类化合物,收率较好(76%～93%).代替了用间氯过氧苯甲酸进行氧化,反应过程稳定,降低了成本.产品的结构经元素分析、IR和1H NMR表征.

关键词: 过氧乙酸, 苯并咪唑类衍生物, 质子泵抑制剂, 氧化

A series of novel pyridine-type derivatives of benzimidazole were synthesized and then oxidized to the corresponding sulfoxides inthe presence of peracetic acid with excellent yields (76%～93%). The process wassafe and economic for industrialization. The structures were established by elemental analysis, IR and 1H NMR spectra.

Key words: peracetic acid, pyridine-type derivative of benzimidazole, proton pump inhibitor, oxidation