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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (9): 1111-1113. 上一篇    下一篇

研究简报

高氯酸镁催化合成1,2,3,4-四氢嘧啶-2-酮

陈维一, 陆军*   

  1. 苏州大学化学化工学院 苏州 215006
  • 收稿日期:2003-05-19 修回日期:2004-04-12 接受日期:2004-04-12 发布日期:2022-09-20

Mg(ClO4)2 as a Powerful Catalyst for Synthesis of 1,2,3,4-Tetrahydropyrimidin-2-ones

CHEN Wei-Yi, LU Jun*   

  1. College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006
  • Received:2003-05-19 Revised:2004-04-12 Accepted:2004-04-12 Published:2022-09-20
  • Contact: * E-mail: orglablj@suda.edu.cn

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在高氯酸镁催化作用下,由醛、1,3-二羰基化合物、脲(硫脲)合成了一系列1,2,3,4-四氢嘧啶-2-酮,此合成方法反应温和、产率高,并且高氯酸镁具有能重复使用的优点.

关键词: Biginelli反应, 高氯酸镁, 醛, 催化剂, 四氢嘧啶-2-酮

Magnesium perchlorate efficiently catalyzes one-pot, three-component Beginelli condensation reactions of aldehydes, 1,3-dicarbonyl compounds and urea or thiourea in acetonitrile to afford the corresponding 1,2,3,4-tetrahydropyrimidin-2-ones in moderate to high yields under neutral conditions. Magnesium perchlorate is also found to exhibit reusable activity.

Key words: Biginelli reaction, Mg(ClO4)2, aldehyde, catalyst, tetrahydropyrimidin-2-ones