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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (9): 1114-1117. 上一篇    下一篇

研究简报

南海海洋真菌#2526中蒽醌类代谢产物的研究

朱峰*,a, 林永成b, 周世宁c   

  1. a佛山科学技术学院化学与化工系 佛山 528000;
    b中山大学化学与化学工程学院 广州 510275;
    c中山大学生命科学学院 广州 510275
  • 收稿日期:2003-12-23 修回日期:2004-03-16 接受日期:2004-04-07 发布日期:2022-09-20
  • 基金资助:
    国家863计划(No. 2001AA624010)资助项目.

Anthraquinone Derivatives Isolated from Marine Fungus #2526 from the South China Sea

ZHU Feng*,a, LIN Yong-Chengb, ZHOU Shi-Ningc   

  1. aDepartment of Chemistry & Chemical Engineering, Foshan University, Foshan 528000;
    bSchool of Chemistry & Chemical Engineering, Zhongshan University, Guangzhou 510275;
    cSchool of Life Science, Zhongshan University, Guangzhou 510275
  • Received:2003-12-23 Revised:2004-03-16 Accepted:2004-04-07 Published:2022-09-20
  • Contact: * E-mail: zsuzhufeng@sohu.com

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从分离自香港红树林的南海海洋真菌#2526的代谢产物中首次同时分离到4个蒽醌类化合物A～D以及sterigmatocystin,通过完整的波谱数据分别解析它们为averufin (A), nidurufin (B), versicolorin C (C)和大黄素甲醚(D);初步生理活性试验表明,化合物A不显示有意义的抑菌活性,并且和化合物D一样,不显示有意义的hTOP I酶抑制活性.

关键词: 海洋真菌, 代谢产物, 蒽醌类化合物, 生理活性

Four anthraquinone derivatives (A～D) and sterigmatocystinwere first isolated simultaneously from the metabolites of mangrove fungus #2526 originated from the South China Sea. Their structures were elucidated as averufin (A), nidurufin (B), versicolorin C (C) and physicion (D) by comprehensive spectrometric methods. In the primary bioassay, compound A did not exhibit significant antibacterial activity and it also had no significant inhibitory activity against DNA topoisomerase (hTOP I) as compound D.

Key words: marine fungus, metabolite, anthraquinone derivative, bioactivity