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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (10): 1288-1291. 上一篇    下一篇

研究简报

N-杂环油酰胺、亚油酰胺的合成及抑菌活性测定

唐文明*, 何湘琼, 宋宝安, 胡德禹, 张智广, 桑维钧, 杨松, 金林红   

  1. 贵州大学精细化工研究开发中心 贵阳 550025
  • 收稿日期:2003-08-12 修回日期:2004-01-13 接受日期:2004-04-27 发布日期:2022-09-20
  • 基金资助:
    国家重点基础研究发展规划(“973”计划,No. 2003CB114404)和国家自然科学基金(No.20162001)资助项目.

Synthesis and Fungicidal Activity of Oleic Amide and LinoleicAmide of N-Heterocycle

TANG Wen-Ming*, HE Xiang-Qiong, SONG Bao-An, HU De-Yu, ZHANG Zhi-Guang, SANG Wei-Jun, YANG Song, JIN Lin-Hong   

  1. Research and Development Center of Fine Chemicals, Guizhou University, Guiyang 550025
  • Received:2003-08-12 Revised:2004-01-13 Accepted:2004-04-27 Published:2022-09-20
  • Contact: * E-mail: sdkyc@163.net

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采用具有天然活性的植物源成分油酸、亚油酸为先导化合物,经过酰氯化、酰胺化,引入高活性的含氮杂环,合成了7个新化合物,经核磁共振氢谱、红外光谱和元素分析测定,确认了新化合物的结构.初步进行了防治中草药半夏、太子参病害的抑菌活性测试.结果表明,部分化合物对半夏枯萎病、太子参轮纹病有一定的抑菌活性.

关键词: 油酸, 亚油酸, 杂环, 酰胺, 抑菌活性

Seven new heterocyclic amide derivatives were synthesised byacylchlorination and then amination of the active ingredient of natural plant. Their structures were confirmed by 1H NMR and IR spectra and elemental analysis. Their anti-bacterium activity testing was carried out. The results of bioassay show that they have fungicidal activities against some Chinese herbal diseases, such as blight of Pinellia ternata and stria disease of Pseudostellaria heterophylla.

Key words: oleic acid, linoleic acid, heterocycle, amide, fungicidal activity