有机化学 ›› 2024, Vol. 44 ›› Issue (3): 871-891.DOI: 10.6023/cjoc202310033 上一篇    下一篇

综述与进展

电化学芳烃C(sp2)—H胺化反应的研究进展

朱子乐, 李鹏飞, 仇友爱*()   

  1. 南开大学化学学院 元素有机化学国家重点实验室 天津 300071
  • 收稿日期:2023-10-31 修回日期:2023-12-13 发布日期:2024-04-02
  • 作者简介:共同第一作者
  • 基金资助:
    国家重点研发计划(2022YFA1503200); 国家自然科学基金(22371149); 国家自然科学基金(22188101); 中央高校基本科研业务费专项资金(63223015); 南开大学有机新物质创造前沿科学中心(63181206)

Recent Advance in Electrochemical C(sp2)—H Amination of Arenes

Zile Zhu, Pengfei Li, Youai Qiu()   

  1. State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071
  • Received:2023-10-31 Revised:2023-12-13 Published:2024-04-02
  • Contact: *E-mail: qiuyouai@nankai.edu.cn
  • About author:The authors contributed equally to this work.
  • Supported by:
    National Key Research and Development Program of China(2022YFA1503200); National Natural Science Foundation of China(22371149); National Natural Science Foundation of China(22188101); Fundamental Research Funds for the Central Universities(63223015); Frontiers Science Center for New Organic Matter, Nankai University(63181206)

苯胺及其衍生物在人类生活和工业生产中被广泛地使用, 促使人们探索从相应的C(sp2)—H键直接构建芳香C(sp2)—N键的反应方法. 近年来, 有机电化学作为一种可控、可持续、环境友好和易于扩展规模的方法, 受到越来越多的关注, 同时也为芳烃的胺化提供了新的反应模式. 在此篇综述中, 总结了电化学芳香族C(sp2)—H胺化反应中常见的机理途径, 根据所涉及的胺源类型对反应实例进行了分类, 并对该领域的前景和挑战提供了见解.

关键词: 电化学, 胺化, 芳烃, 苯胺, C—H键胺化

Aniline and its derivatives are widely used and consumed in human life and industrial production, which inspires the direct aromatic C(sp2)—N construction from the corresponding C(sp2)—H bond. In recent years, as a controllable, sustainable, ambient, and highly scalable methodology, organic electrochemistry has received greater attention and also combined aromatic C(sp2)—N amination, presenting novel reactions. In this review, the common mechanism manifolds of electrochemical aromatic C(sp2)—H amination reactions are summarized, and the reactions examples are classified according to the type of amine sources. The prospects and challenges in this field are provided.

Key words: electrochemistry, amination, arene, aniline, C—H amination