聚集诱导发光分子纳米酶复合材料的研究进展

doi:10.6023/cjoc202403040

摘要/Abstract

聚集诱导发光(aggregation-induced emission, AIE)分子是近年来荧光材料研究领域中的明星分子, 在聚集态具有高的发光效率以及优异的活性氧产生能力. 纳米酶是一类具有类酶催化性能的纳米材料, 具有良好的生物相容性和优异的酶催化活性. AIE分子与纳米酶结合的纳米复合材料兼具AIE分子与纳米酶的独特性能. 综述了AIE分子纳米酶复合材料的制备以及在化学/生物传感、光学诊疗等领域的最新研究成果, 并对其存在的不足和未来发展前景进行了展望.

关键词: 聚集诱导发光, 纳米酶, 化学/生物传感, 光学诊疗

Aggregation-induced emission (AIE) molecule is the most prominent molecule in the fluorescent materials in recent years, and it has high luminous quantum efficiency and excellent capability to produce active oxygen species in the aggregated state. Nanozyme is a kind of nanomaterial with enzyme-like catalytic performance, which has good biocompatibility and excellent enzymatic catalytic activity. The nanocomposites combined with AIE molecule and nanozyme have the unique properties of AIE molecules and nanozyme. In this paper, the preparation of AIE molecule and nanozyme composites and the latest research achievements in the field of chem/biosensing and optical diagnosis and treatment are reviewed. Finally, the shortcomings and future development are also prospected.

Key words: aggregation-induced emission, nanozyme, chem/biosensing, optical diagnosis and treatment

引用此文

张洁, 李楠, 赵娜. 聚集诱导发光分子纳米酶复合材料的研究进展[J]. 有机化学, 2024, 44(8): 2469-2478.

Jie Zhang, Nan Li, Na Zhao. Recent Progress of Aggregation-Induced Emission Molecule Nanozyme Composites[J]. Chinese Journal of Organic Chemistry, 2024, 44(8): 2469-2478.

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图/表 9

图1. (A)酶级联激活系统AOX/CeO2@TPE＋OPD在比例荧光-比色双模式下响应CH3SH的总体设计原理图、(B) TPE的结构式、(C)视觉比色模式下G/B与CH3SH浓度的定量曲线、(D)荧光模式下G/B与CH3SH浓度的定量曲线[67]

Figure 1. (A) Schematic diagram of the overall design of the enzyme cascade activation system AOX/CeO2@TPE＋OPD in response to CH3SH in a proportional fluorimetric colorimetric dual mode, (B) structural formula of TPE, (C) quantitative curves of G/B and CH3SH concentrations in visual colorimetric model and (D) quantitative curves of G/B and CH3SH concentrations in fluorescence model[67] Copyright 2023, American Chemical Society

图2. 基于MCOF-Au NPs@apt和TPE-4A对鼠伤寒沙门氏菌比色/荧光双模检测原理图[68]

图3. (A) PMD在结肠癌原位介入光动力治疗中的应用原理图、(B) DCPy的结构式、(C)注射PMD 6 h后原位CT26荷瘤小鼠的肿瘤和采集器官的体外图像、(D)内窥镜定位腹腔内的肿瘤并使用激光通过光纤开始PDT治疗[72]

Figure 3. (A) Schematic diagram of PMD in in situ interventional photodynamic therapy for colon cancer, (B) structural formula of DCPy, (C) in vitro images of tumor and organ collection of CT26 tumor bearing mice in situ 6 h after PMD injection and (D) endoscope localization of tumor in abdominal cavity and initiation of PDT therapy through optical fiber using laser[72] Copyright 2022, American Chemical Society

图4. (A) Lipo-OGzyme-AIE在细胞内的级联反应的原理图、(B) AIE分子的结构、(C)在100 μmol/L的H2O2溶液中不同pH值下溶解的O2水平的动态变化, 以及在白光照射下Lipo-AIE、Lipo-OGzyme-AIE的ABDA的分解率[73]

Figure 4. (A) Schematic diagram of the cascade reaction of Lipo-OGzyme-AIE, (B) structural formula of the AIE molecule and (C) the dynamic change of dissolved O2 levels at different pH values in H2O2 solution of 100 μmol/L, and the decomposition rate of ABDA of Lipo-AIE and Lipo-OGzyme-AIE under white light irradiation[73] Copyright 2019, Elsevier Ltd.

图5. (A) BTZ/Fe2＋@BTF/ALD用于乳腺癌骨转移瘤的NIR-II PTT/化疗/CDT原理图、(B) BBT-FT-DA的结构式、(C)尾静脉注射BTZ/Fe2＋@BTF/ALD的小鼠NIR-II荧光和光声成像图像[74]

Figure 5. (A) Schematic diagram of BTZ/Fe2＋@BTF/ALD for NIR-II PTT/chemotherapy/CDT in breast cancer with bone metastases, (B) structural formula of BBT-FT-DA and (C) NIR FL image and PA image of mice injected with BTZ/Fe2＋@BTF/ALD by tail vein[74] Copyright 2022, Advanced Science published by Wiley-VCH GmbH

图6. (A) PTC诱导细胞铜死亡原理图、(B) TBP-2的结构式、(C)经不同条件处理后从小鼠中收集到的肺部组织(蓝色箭头表示转移病灶)[75]

Figure 6. (A) Schematic diagram of cuproptosis induced by PTC, (B) structural formula of TBP-2 and (C) lung tissue collected from mice after treatment under different conditions (blue arrows indicate metastatic lesions)[75] Copyright 2023, American Chemical Society

图7. (A) Zn@MOF-TPD的制备过程及其对加速脊髓损伤后恢复的机理原理图、(B)不同处理后小鼠染色氧化应激的代表性图像、(C)脊髓损伤2个月后的宏观照片(白色箭头表示放大图像中损伤脊髓的位置)[76]

Figure 7. (A) Schematic diagram of the preparation process of Zn@MOF-TPD and its mechanism for accelerating recovery after spinal cord injury, (B) representative images of stained oxidative stress in mice after different treatments and (C) macro photos of spinal cord injury 2 months after treatment (the white arrow indicates the location of the damaged spinal cord in the enlarged image)[76] Copyright 2024, American Chemical Society.

图8. (A) ARC制备工艺及肿瘤治疗原理图、(B) 808 nm激光照射前后的体外ARC中CQu释放曲线(红色箭头表示照射时间点)、(C)瘤内注射ARC或PB＋CQu后1, 24和48 h的荧光成像图[77]

Figure 8. (A) Schematic diagram of ARC preparation process and its tumor therapy, (B) in vitro ARC CQu release profile in the presence and absence of 808 nm laser irradiation (red arrows being used to indicate irradiation time points) and (C) fluorescence images for mice after intratumoral ARC or PB＋CQu injection 1, 24 and 48 h[77] Copyright 2019, Elsevier Ltd.

图9. (A) 2TT-mC6B@Cu5.4O纳米粒子的合成原理图、(B) 2TT-mC6B的结构式和(C) 2TT-mC6B@Cu5.4O纳米粒子对深层感染愈合和炎症抑制的示意图[78]

Figure 9. (A) Synthesis diagram of 2TT-mC6B@Cu5.4O NPs, (B) structural formula structure of 2TT-mC6B, and (C) schematic diagram of 2TT-mC6B@Cu5.4O NPs for deep infection healing and inflammation inhibition[78] Copyright 2023, Wiley-VCH GmbH

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