聚集诱导发光材料在肿瘤光治疗应用中的最新进展

doi:10.6023/cjoc202403058

摘要/Abstract

癌症是世界上导致死亡的主要原因之一, 其发病率不断上升. 光疗以其无创、无耐受性、副作用小和操作方便等优势, 已成为癌症精准治疗的新范式. 自2001年唐本忠院士团队发现聚集诱导发光(AIE)现象以来, 具有该性质的荧光材料被广泛用作高效光敏/光热试剂. 因其高度扭曲的分子结构, 避免了聚集态下的平面堆叠问题, 从根本上解决了传统荧光材料聚集淬灭现象, 显著提高了量子产率和光稳定性. 作者详细对AIE材料作为光敏剂、光热剂及显影剂在癌症光疗(光动力治疗、光热治疗和光声成像)以及联合治疗中的最新应用进行了综述, 并展望其未来发展趋势.

关键词: 聚集诱导发光, 光动力治疗, 光热治疗, 多模态联合治疗

Cancer is a leading cause of death globally with its incidence rate on the rise. Phototherapy has emerged as a novel approach for precise cancer treatment, offering benefits such as non-invasiveness, no drug resistance, minimal side effects, and ease of operation. Since Prof. Ben Zhong Tang conceptually coined aggregation-induced emission (AIE) in 2001, AIE materials have been extensively applied as efficient photosensitive and photothermal agents. Thanks to their highly twisted molecular structure, AIE materials avoid the issue of π-π stacking in aggregated states, thereby fundamentally addressing the aggregation-caused quenching problem observed in traditional fluorescent materials. This advancement leads to a significant enhancement in quantum yield and photostability. Herein, the author comprehensively reviews the latest applications of AIE materials as photosensitizers, photothermal agents, and diagnostic agents in cancer phototherapy.

Key words: aggregation-induced emission, photodynamics therapy, photothermal therapy, multimodal combination therapy

引用此文

孟子翔, 田秀梅, 张天富. 聚集诱导发光材料在肿瘤光治疗应用中的最新进展[J]. 有机化学, 2024, 44(8): 2441-2452.

Zixiang Meng, Xiumei Tian, Tianfu Zhang. Recent Progress of Aggregation-Induced Emission Materials in Tumor Phototherapy[J]. Chinese Journal of Organic Chemistry, 2024, 44(8): 2441-2452.

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图/表 16

图1. TPETCAQ纳米粒子的制备[21]

Figure 1. Preparation of TPETCAQ nanoparticles

图2. CPy、CQu、DCPy和DCQu四种分子的结构

Figure 2. Structures of four molecules CPy, CQu, DCPy, and DCQu

图3. 不同PS存在下ABDA在光照下的分解[22]

Figure 3. Decomposition of ABDA under illumination in the presence of different PSs

图4. 三种分子TPS-0、TPS-1和TPS-2的结构

Figure 4. Structures of three molecules TPS-0, TPS-1, and TPS-2

图5. TATIC分子结构及其光动力性能[24]

Figure 5. Molecular structure of TATIC and its photodynamic properties

图6. α-TPA-PIO和β-TPA-PIO分子结构

Figure 6. Structures of α-TPA-PIO and β-TPA-PIO

图7. P1聚合物及其量子产率[30]

Figure 7. P1 polymer and its quantum yield

图8. PTPEAQ聚合物的结构

Figure 8. Structure of PTPEAQ polymer

图9. CP1~CP4的结构

Figure 9. Structures of CP1~CP4

图10. IR-797分子结构及其光热成像[36]

Figure 10. Structure of IR-797 and its photothermal imaging

图11. BPBBT分子结构及其光热性能[37]

Figure 11. Structure of BPBBT and its photothermal property

图12. BBT-C6T-DPA(OMe)分子结构及其光热性能[38]

Figure 12. Structure of BBT-C6T-DPA(OMe) and its photothermal property

图13. NIRb14等分子应用于光声成像[43]

Figure 13. Application of NIRb14 in PA imaging

图14. TTPY-Py的制备及其在PAI协同PDT-PTT中的应用[50]

Figure 14. Preparation of TTPY-Py and its application in PAI collaborative PDT-PTT

图15. TISSI的制备及其多功能光疗应用[51]

Figure 15. Preparation of TISSI and its multifunctional phototherapy application

图16. DDTB分子结构及其在多功能手术和光疗中的应用[52]

Figure 16. Structure of DDTB and its applications in multifunctional surgery and phototherapy

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