聚集诱导发光材料在肿瘤光治疗应用中的最新进展

doi:10.6023/cjoc202403058

摘要/Abstract

癌症是世界上导致死亡的主要原因之一,其发病率不断上升。光疗以其无创、无耐受、小副作用、操作方便等优势,已成为癌症精准治疗的新范式。自2001年唐本忠院士团队发现聚集诱导发光(AIE)现象以来,具有该性质的荧光材料被广泛用作高效光敏/光热试剂。因其高度扭曲的分子结构,避免了聚集态下的平面堆叠问题,从根本上解决了传统荧光材料聚集淬灭现象,显著提高了量子产率和光稳定性。作者详细对AIE材料作为光敏剂、光热剂及显影剂在癌症光疗(光动力治疗、光热治疗、光声成像)以及联合治疗中的最新应用进行了综述,并展望其未来发展趋势。

关键词: 聚集诱导发光, 光动力治疗, 光热治疗, 多模态联合治疗

Cancer is a leading cause of death globally, with its incidence rate on the rise. Phototherapy has emerged as a novel approach for precise cancer treatment, offering benefits such as non-invasiveness, tolerability, minimal side effects, and ease of operation. Since Prof. Ben Zhong Tang conceptually coined aggregation-induced emission (AIE) in 2001, AIE materials have been extensively applied as efficient photosensitive and photothermal agents. Thanks to their highly twisted molecular structure, AIE materials avoid the issue of π-π stacking in aggregated states, thereby fundamentally addressing the aggregation-caused quenching problem observed in traditional fluorescent materials. This advancement leads to a significant enhancement in quantum yield and photostability. Herein, the author comprehensively reviews the latest applications of AIE materials as photosensitizers, photothermal agents, and diagnostic agents in cancer phototherapy.

Key words: Aggregation-induced emission, Photodynamics therapy, Photothermal therapy, Multimodal combination therapy

引用此文

孟子翔, 田秀梅, 张天富. 聚集诱导发光材料在肿瘤光治疗应用中的最新进展[J]. 有机化学, doi: 10.6023/cjoc202403058.

Meng, Zixiang, Tian, Xiumei, Zhang, Tianfu. Recent progress of aggregation-induced emission materials in tumor phototherapy[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202403058.

导出引用 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

分享此文

参考文献

[1] Jiang, W.G.; Sanders, A.J.; Katoh, M.; Ungefroren, H.; Gieseler, F.; Prince, M.; Thompson, S.K.; Semin. Cancer Biol. 2015, 35, S244.
[2] Sung H.; Ferlay J.; Siegel RL.; Laversanne M.; Soerjomataram I.; Jemal A.; Bray, F. CA Cancer J Clin.2021, 71, 209.
[3] Siegel R.L.; Miller K.D.; andJemal, A. CA Cancer J. Clin.2023, 73, 17.
[4] Jia S.; Yuan H. and Hu R. Biomater. Sci.2022, 10, 4443.
[5] Jiang Z.; Zhang C.; Wang X.; Yan M.; Ling Z.; Chen Y. and Liu, Z. Angew. Chem.Int. Ed.2021, 60, 22376.
[6] Qu R.; Zhen X. and Jiang X. CCS Chem.2022, 4, 401.
[7] Zhou,Z.; Li,B.; Shen,C.; Wu,D.; Fan H.; Zhao J.; Li H.; Zeng Z.; Luo,Z.; Ma L.; Tan C. Small2020, 16, 2004173.
[8] Yu G.; Yang Z.; Fu X.; Yung B.C.; Yang J.; Mao Z.; Shao L.; Hua B.; Liu Y. Commun.2018, 9, 766.
[9] Zhou Z.; Wang X.; Zhang H.; Huang H.Small. 2021, 17, 2007486
[10] Zhao, Y.; Chen, P.; Han, L.; Wang, E.; Chin. J. Org. Chem. 2023, 7, 2454 (in Chinese).
(赵洋, 陈盼盼, 韩立志, 王恩举, 有机化学,2023, 7, 2454.)
[11] Zhao Y.; Chen P.; Li G.; Niu Z.; Wang E.Chin. J. Org. Chem. 2023, 43, 2156 (in Chinese).
(赵洋陈盼盼李高楠钮智刚王恩举, 有机化学,2023,43, 2156.)
[12] Lu H.; Ma La.; Ma, Heng. Chin. J. Org. Chem.2023, 43, 4075 (in Chinese).
(鲁会名, 马拉毛草, 马恒昌, 有机化学,2023, 43, 4075.)
[13] Lyu, X.; Yu, J.; Zhang, L.; Zhao, Y.; Qiu, Z.; Chen, Y.; Zhao, Z.; Tang, B.Z.; J. Mater. Chem. B. 2023, 11, 5953.
[14] Hu F.; Liu B. Biomol. Chem.2016, 14, 9931.
[15] Dharmaraja, A.T. J. Med. Chem. 2017, 60, 3221.
[16] Feng, G. and Liu, B. Acc. Chem. Res., 2018, 51, 1404.
[17] Wang D.; andTang, B.Z. Acc. Chem. Res.,2019, 52, 2559.
[18] Zhao,Y.; Zhang X.; Yang Y.;Zhu L.; Zhou Y. Acta Chimica Sinica,2024, 82, 265(in Chinese).
(赵玉强, 张霞, 杨芸如, 朱立平, 周莹, 化学学报,2024, 82, 265)
[19] Qu R.; Zhen Xu. and Jiang X. CCS Chem.2022, 4, 401.
[20] Xu, S.; Wu, W.; Cai, X.; Zhang, C.; Yuan, Y.; Liang, J.;Feng, G.; Manghnani, P.; Liu, B.; Chem. Commun. 2017, 53, 8727.
[21] Wu, W.; Mao, D.; Hu, F.; Xu, S.; Chen, C.; Zhang, C.; Adv. Mater., 2017, 29, 1700548.
[22] Zheng Z.; Liu H.; Zhai S.; Zhang H.; Shan G.; Kwok R.; Ma C.; Sung H.; Williams I.; Lam J.; Wong K.; Hu X.; Tang B.Z. Chem. Sci.2020, 11, 2494.
[23] Zhang T.; Yang X.; Ou X.; Lee M.M.S.; Zhang J.; Xu C.; Yu,X.; Gong P.; Lam J.W.Y.; Zhang P.; Tang B.Z.Adv. Mater.2023, 35, 2303186.
[24] Yang Z.; Zhang Z.; Sun Y.; Lei Z.; Wang D.; Ma H.; Tang B.Z. Biomaterials2021, 275, 120934.
[25] Zhuang Z.; Dai J.; Yu M.; Li J.; Shen P.; Hu R.; Lou X.; Zhao Z.; Tang B.Z. Chem. Sci.2020, 11, 3405.
[26] Qin A.; Lam J.W.Y.; Tang, B.Z. Prog. Polym. Sci.2012, 37, 182.
[27] Zhang Y.; Ju J.;Wang D.;Yuan H.; Hao L.; Tan, Y. J. Mater. Chem. C.2021. 9, 11484.
[28] Hu,R.; Qin A.; Tang, B.Z. Prog. Polym. Sci.2020, 100, 101176.
[29] Hu R.; Leung N.L.C.; Tang, B.Z. Chem. Soc. Rev.2014, 43, 4494.
[30] Liu S.; Zhang H.; Li Y.; Liu J.; Du L.; Chen M.; Kwok R.T.K.; Lam J.W.Y.; Phillips D.L.; Tang, B.Z. Angew. Chem. Int. Ed.2018, 57, 15189.
[31] Wu W.; Feng,G.; Xu S.; Liu B. Macromolecules2016, 49, 5017
[32] Wu W.; Mao D.; Xu S.; Kenry R.; Hu F.;Li X.; Kong D.; Liu B.;Chem. 2018, 4, 1937.
[33] Jung H. S.; Verwilst P.; Sharma A.; Shin J.; Sessler J. L. and Kim, J. S. Chem. Soc. Rev.2018, 47, 2280.
[34] Xu H.; Han P.; Qin A.; Tang, B.Z. Acta Chimica Sinica2023, 81, 1420(in Chinese).
(徐赫, 韩鹏博, 秦安军, 唐本忠, 化学学报,2023, 81, 1420)
[35] Yu J.;Ju Y.; Zhao L.;Chu X.; Yang W.; Tian Y.; Sheng F.; Lin J.; Liu F.; Dong Y. and Hou Y. ACS Nano.2016, 10, 159.
[36] Xiao Y.; An F.; Chen J.X.; Yu J.; Tao W.W.; Yu Z.; Ting R.; Lee C.S.; Zhang X.H. Small2019, 15, 1903121.
[37] Gao S.; Wei G.; Zhang S.; Zheng B.; Xu J.; Chen G.; Li M.; Song S.; Fu W.; Xiao Z.; Lu W. Nat. Commun.2019, 10, 2206.
[38] Zhang M.; Wang W.; Mohammadniaei M.; Zheng T.; Zhang Q.; Ashley J.; Liu S.; Sun Y.; Tang B.Z. Adv. Mater.2021, 33, 2008802.
[39] Ni J.; Li,Y.; Yue W.; Liu B.; Li K.Theranostics 2020, 10, 1923.
[40] Ni J.; Zhang P.; Jiang T.; Chen Y.; Su H.; Wang D.; Yu Z.; Kwok R.; Zhao Z.; Lam J.; Tang B.Z.Adv. Mater. 2018, 238, 119834.
[41] Li, J.and Pu, K. Chem. Soc. Rev. 2019, 48, 38.
[42] He X.; Peng C.; Qiang S. Biomaterials2020,238,119834.
[43] Liu S.; Zhou X.; Zhang H.; Ou H.; Lam J.W.Y.; Liu Y.; Shi L.; Ding D.; Tang, B.Z. J. Am. Chem. Soc.2019, 141, 5359.
[44] Lang,T.; Liu,Y.; Zheng,Z.; Ran,W.; Zhai,Y.; Yin, Q.; Zhang, P.; Li, Y.; Adv. Mater. 2019, 31, 1806202.
[45] Liu J.; Song L.; Liu S.; Jiang Q.; Liu Q.; Li N.; Wang Z.G.; Ding B. Nano Lett.2018, 18, 3328.
[46] Xie,Z.; Fan,T.; An J.; Choi W.; Duo Y.; Ge Y.; Zhang B.; Nie,G.; Xie N.;Zheng T.; Chen Y.; Zhang,H.; Kim, J.S. Chem. Soc. Rev.2020, 49, 8065.
[47] Sun,L.; Wang,D.; Chen,Y.; Wang L.; Huang P.; Li Y.; Liu Z.; Yao H.; Shi J. Biomaterials2017,133, 219.
[48] Xie Z.; Fan T.; An J.; Choi W.; Duo Y.; Ge Y.; Zhang B.; Nie G.; Xie N.; Zheng T.; Chen Y.; Zhang H.; Kim, J.S. Chem. Soc. Rev.2020, 49, 8065.
[49] Xu C.; Ye R.; Shen H.; Lam J.W.Y.; Zhao, Z.; Tang, B.Z.Angew. Chem. Int. Ed. Engl. 2022, 61, e202204604.
[50] Song N.; Zhang, Z,; Liu P.; Dai D.; Chen C.;Li Y.; Wang L.;Han T.;Yang Y.;Wang D.;Tang, B.Z. Adv. Funct. Mater.2021, 31, 2009924.
[51] Zhang Z.; Xu W.; Kang M.; Wen H.; Guo H.; Zhang P.; Xi L.; Li K.; Wang L.; Wang D.; Tang B.Z. Adv. Mater.2020, 32, 2003210.
[52] Jiang R.; Dai J.; Dong X.; Wang Q.; Meng Z.; Guo J.; Yu Y.; Wang S.; Xia F.; Zhao Z.; Lou X.; Tang B.Z. Adv. Mater.2021, 33, 2101158.