酰胺噁唑啉导向的铜催化[2.2]对环芳烷直接C–H酰氧基化反应

doi:10.6023/cjoc202602012

研究论文

酰胺噁唑啉导向的铜催化[2.2]对环芳烷直接C–H酰氧基化反应

韩银松, 王东炜, 肖佳怡, 冯若昆^*

^a绍兴大学化学化工学院浙江绍兴 312000

收稿日期:2026-02-10 修回日期:2026-04-05
基金资助:
浙江省自然科学基金 (No. LQ15B020002), 绍兴市重点科技创新团队项目绍兴市科技计划 (202034)和国家级大学生创新创业训练计划 (No. 202410349028)资助项目.

Amide-Oxazoline-Directed Copper-Catalyzed C-H Acyloxylation of [2.2]Paracyclophanes

Han Yinsong, Wang Dongwei, Xiao Jiayi, Feng Ruokun^*

^aCollege of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, 312000

Received:2026-02-10 Revised:2026-04-05
Contact: *E-mail: fengshenghm86@usx.edu.cn
Supported by:
Zhejiang Provincial Natural Science Foundation of China (Grant LQ15B020002), the Shaoxing Key Science and Technology Innovation Team Project (202034), and the National College Students' Innovation and Entrepreneurship Training Program (No. 202410349028).

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摘要/Abstract

报道了一种基于廉价金属铜催化、利用酰胺噁唑啉导向基团实现的[2.2]对环芳烷直接Csp²—H酰氧化反应。该反应体系适用于芳香羧酸、烯基羧酸及烷基羧酸等多种羧酸底物,能以中等到良好的产率获得目标产物。克级规模实验及后续水解反应进一步证明了该方法的合成实用性。本研究为[2.2]对环芳烷的选择性官能化提供了一种高效、便捷的合成策略,具有潜在的应用前景。

关键词: 铜催化, 酰胺噁唑啉导向, C–H酰氧基化, [2.2]对环芳烷

A copper-catalyzed direct C-H acyloxylation of [2.2]paracyclophanes utilizing an oxazoline amide directing group has been developed. A range of carboxylic acid substrates, including aromatic, alkenyl, and alkyl carboxylic acids, are tolerated, delivering the corresponding acyloxylated products in moderate to good yields. Gram-scale reactions and subsequent hydrolysis experiments further demonstrate the synthetic utility of this method. This work provides an efficient and convenient strategy for the selective functionalization of [2.2]paracyclophanes, highlighting its potential for practical applications.

Key words: Copper catalysis, Amide oxazoline directed, C-H acyloxylation, [2.2]Paracyclophanes

引用此文

韩银松, 王东炜, 肖佳怡, 冯若昆. 酰胺噁唑啉导向的铜催化[2.2]对环芳烷直接C–H酰氧基化反应[J]. 有机化学, doi: 10.6023/cjoc202602012.

Han Yinsong, Wang Dongwei, Xiao Jiayi, Feng Ruokun. Amide-Oxazoline-Directed Copper-Catalyzed C-H Acyloxylation of [2.2]Paracyclophanes[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202602012.

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