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封面介绍N-Heterocyclic carbene (NHC) is a kind of important small organic molecule catalyst, which plays a key role in the field of organic catalysis. A series of important advances have been made in the study of the umpolung of aldehyde compounds catalyzed by NHC. NHC cata-lyzed the umpolung of aldehyde compounds is intro-duced by Zhao, Yan and Chen on page 2204.
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封面介绍A transition-metal-free strategy for the synthesis of tetrasubstituted furans is reported by Meng, Guo and Wang on page 2274. Promoted by boron trifluoride di-ethyl etherate, the reaction of alkynyl sulfoxides with ynamides/ynol ethers proceeded via a cascade process including cross-coupling of the two reactants, [3,3]- sulfonium rearrangement, and 5-exo-dig heterocyclization, leading to tetrasubstituted furan products.
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封面介绍Based on our previous total synthesis of complex natural product elansolid A, a simplified analog of elansolid A featured with a cyclohexyl-fused 19-memebered macro-lactone was proposed, and its asymmetric total synthesis based on a convergent strategy and key reactions exem-plified by desymmetric alcoholysis of anhydride, Pd- catalyzed Stille coupling, Suzuki-Miyaura coupling as well as Mukaiyama macrolactonization was finished by Yang, Wu and Wang on page 2350.
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封面介绍A manganese-catalyzed ring-opening C—C bond fluorination of cyclobutanols is reported by Wang, Liu, Zan, Sun, Liu, Li, and Liu on page 2333. Under mild conditions, the reaction provides a straightforward access to γ-fluorinated ketones using 10 mol% Mn(OAc)2 as catalyst and electro- philic fluorination reagent, which was generated in situ from HF·Et3N and PhIO, as fluorine source.
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