Synthesis and Biological Activity of N-Substituted Benzylidene-4-(4-methoxyphenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-thiazol-2-amine

doi:10.6023/cjoc1202242

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (9): 1715-1718.DOI: 10.6023/cjoc1202242 Previous Articles Next Articles

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N-芳亚甲基-4-(4-甲氧基苯基)-5-(1H-1,2,4-三唑-1-基)-1,3-噻唑-2-胺的合成与生物活性

戴红^a,b, 周欣^a, 邵玲^a, 刘建兵^a, 秦雪^a, 方建新^a

a 南开大学元素有机化学国家重点实验室天津 300071;
b 南通大学化学化工学院南通 226019

收稿日期:2012-02-24 修回日期:2012-05-11 发布日期:2012-03-30
通讯作者: 方建新 E-mail:daihong_2001@yahoo.com.cn, fjx@nankai.edu.cn
基金资助:
国家自然科学基金(No.20772068)、南通市科技计划(Nos.AS2010005, AS2011011)资助项目

Synthesis and Biological Activity of N-Substituted Benzylidene-4-(4-methoxyphenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-thiazol-2-amine

Dai Hong^a,b, Zhou Xin^a, Shao Ling^a, Liu Jianbing^a, Qin Xue^a, Fang Jianxin^a

a State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071;
b College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019

Received:2012-02-24 Revised:2012-05-11 Published:2012-03-30
Supported by:
Project supported by the National Natural Science Foundation of China (No.20772068), the Science and Technology Projects Fund of Nantong City (Nos.AS2010005, AS2011011)

Reaction of 2-amino-4-(4-methoxyphenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-thiazole with various substituted benzal-dehydes produced a series of novel thiazole Schiff bases containing 1H-1,2,4-triazole ring. Their structures were characterized by ¹H NMR spectra and elemental analysis. The bioassay data indicated that some of the title compounds showed certain antitumor activities.

Key words: thiazole, 1H-1,2,4-triazole, synthesis, bioactivity

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Dai Hong, Zhou Xin, Shao Ling, Liu Jianbing, Qin Xue, Fang Jianxin. Synthesis and Biological Activity of N-Substituted Benzylidene-4-(4-methoxyphenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-thiazol-2-amine[J]. Chin. J. Org. Chem., 2012, 32(9): 1715-1718.

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N-芳亚甲基-4-(4-甲氧基苯基)-5-(1H-1,2,4-三唑-1-基)-1,3-噻唑-2-胺的合成与生物活性

Synthesis and Biological Activity of N-Substituted Benzylidene-4-(4-methoxyphenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-thiazol-2-amine

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